Evidence map›Paper›PMID 37152293›Full record

ArticleFrontiers in cell and developmental biology2023

Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells.

Meng Zhou, Manling Zhang, Tianxu Guo, Lihua Zhao, Xiyun Guo, Zhibao Yin, Linxin Cheng, Han Liu, Lixia Zhao, Xihe Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Porcine Kidney Organoids Derived from Naïve-like Embryonic Stem Cells.International journal of molecular sciences · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Meng ZhouJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Manling ZhangJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Tianxu GuoJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Lihua ZhaoJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Xiyun GuoJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Zhibao YinJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Linxin ChengJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Han LiuJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Lixia ZhaoThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia, China.
Xihe LiThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia, China.
Rongfeng LiJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CNInner Mongolia University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incomplete silencing of exogenous transcription factors (TFs) and the lack of endogenous counterpart activation hampers the application of porcine induced pluripotent stem cells (piPSCs). We used porcine, bovine and murine TFs to reprogram porcine fetal fibroblasts. Porcine TFs-derived piPSCs (ppiPSCs) showed the highest levels of endogenous pluripotency markers activation, were able to differentiate into three germ layers and primordial germ cell-like cells (PGCLCs) and integrated into neural ectoderm of E7.5 mouse embryos

Indexed as

activationendogenous pluripotency markerexogenous transcription factorsporcine induced pluripotent stem cellsspecies

Identifiers

PMID37152293
PMCPMC10160484
OpenAlexW4366773678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.