Evidence map›Paper›PMID 37152005›Full record

ArticleFrontiers in oncology2023

Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer.

Congling Yang, Santosh K Tiwari, Lianshan Guo, Guanghui An, Heming Zheng, JianFeng Huang, Li Jiang, Zhihao Bai, Yanqiu Zhu, Nannan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Congling YangKey Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Institute Fullerene Technology (GIFT), Ministry of Education, School of Resources, Environment and Materials, Guangxi University, Nanning, Guangxi, China.
Santosh K TiwariKey Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Institute Fullerene Technology (GIFT), Ministry of Education, School of Resources, Environment and Materials, Guangxi University, Nanning, Guangxi, China.
Lianshan GuoDepartment of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Guanghui AnKey Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Institute Fullerene Technology (GIFT), Ministry of Education, School of Resources, Environment and Materials, Guangxi University, Nanning, Guangxi, China.
Heming ZhengKey Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Institute Fullerene Technology (GIFT), Ministry of Education, School of Resources, Environment and Materials, Guangxi University, Nanning, Guangxi, China.
JianFeng HuangDepartment of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Li JiangDepartment of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhihao BaiKey Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Institute Fullerene Technology (GIFT), Ministry of Education, School of Resources, Environment and Materials, Guangxi University, Nanning, Guangxi, China.
Yanqiu ZhuKey Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Institute Fullerene Technology (GIFT), Ministry of Education, School of Resources, Environment and Materials, Guangxi University, Nanning, Guangxi, China.
Nannan WangKey Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Institute Fullerene Technology (GIFT), Ministry of Education, School of Resources, Environment and Materials, Guangxi University, Nanning, Guangxi, China.
Guangxi University · CNGuangxi Medical University · CNFirst Affiliated Hospital of GuangXi Medical University · CNUniversity of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The toxic effects of chemotherapy drugs on normal tissues are still a major limiting factor in cancer treatment. In this paper, we report a metal-organic framework (Zn-Co ZIF) with chitosan-coated outer layer as a carrier for the drug adriamycin hydrochloride (DOX), a treatment for liver cancer, as a novel anti-cancer nanodrug-enhanced carrier. Gold nanoparticles, a good photothermal conversion agent, were combined with the target SH-RGD during surface functionalisation to prepare Zn-Co ZIF@DOX-CS-Au-RGD (ZD-CAR), a nanoplatform with good photothermal conversion properties and targeting for combined liver cancer therapy. ZD-CAR was developed after RGD accurately targeted the tumour and entered the tumour microenvironment (TME), it cleaves and releases the liver cancer therapeutic agent (DOX) in a weak acidic environment to effectively kill tumour cells. The metal skeleton cleavage releases Co

Indexed as

alleviating hypoxiachemo-photothermal therapydrug deliverypH sensitivityZn-Co MoF

Identifiers

PMID37152005
PMCPMC10154549
OpenAlexW4366429329

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.