Evidence map›Paper›PMID 37151606›Full record

ArticleOxidative medicine and cellular longevity2023

Epiisopiloturine, an Alkaloid from

João Antônio Costa de Sousa, Francisco Vinícius Clemente Serra Azul, Ana Bruna de Araújo, Rebeca Colares Tomé, Francisca Raysse Mesquita Silva, Silvânia Maria Mendes de Vasconcelos, Francisco José Rios, Luzia Kalyne Almeida Moreira Leal

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

João Antônio Costa de SousaCenter of Cosmetics and Pharmaceutical Studies, CEFAC, Faculty of Pharmacy, Odontology, and Nursing, Department of Pharmacy, Federal University of Ceará, CEFAC, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0002-9760-3056
Francisco Vinícius Clemente Serra AzulCenter of Cosmetics and Pharmaceutical Studies, CEFAC, Faculty of Pharmacy, Odontology, and Nursing, Department of Pharmacy, Federal University of Ceará, CEFAC, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0002-7958-2044
Ana Bruna de AraújoCenter of Cosmetics and Pharmaceutical Studies, CEFAC, Faculty of Pharmacy, Odontology, and Nursing, Department of Pharmacy, Federal University of Ceará, CEFAC, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0002-4436-6093
Rebeca Colares ToméCenter of Cosmetics and Pharmaceutical Studies, CEFAC, Faculty of Pharmacy, Odontology, and Nursing, Department of Pharmacy, Federal University of Ceará, CEFAC, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0001-5412-5624
Francisca Raysse Mesquita SilvaCenter of Cosmetics and Pharmaceutical Studies, CEFAC, Faculty of Pharmacy, Odontology, and Nursing, Department of Pharmacy, Federal University of Ceará, CEFAC, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0001-5303-2696
Silvânia Maria Mendes de VasconcelosNeuropharmacology Laboratory, Department of Physiology and Pharmacology, NPDM, Federal University of Ceará, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0003-1478-0127
Francisco José RiosInstitute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.ORCID https://orcid.org/0000-0002-8194-0787
Luzia Kalyne Almeida Moreira LealCenter of Cosmetics and Pharmaceutical Studies, CEFAC, Faculty of Pharmacy, Odontology, and Nursing, Department of Pharmacy, Federal University of Ceará, CEFAC, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0003-0090-7991
Universidade Federal do Ceará · BRUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation is present in the pathophysiological mechanisms of several diseases that affect the central nervous system (CNS). Microglia have a prominent role in initiating and sustaining the inflammatory process. Epiisopiloturine (EPI) is an imidazole alkaloid obtained as a by-product of pilocarpine extracted from

Indexed as

AlkaloidsAntineoplastic AgentsPilocarpus4-ButyrolactoneAnti-Inflammatory AgentsCell LineHumansImidazolesLipopolysaccharidesMAP Kinase Signaling SystemMicrogliaNeuroinflammatory DiseasesNF-kappa BNitric OxideSignal TransductionToll-Like Receptor 44-ButyrolactoneAlkaloidsAnti-Inflammatory AgentsAntineoplastic AgentsepiisopiloturineImidazolesLipopolysaccharidesNF-kappa BNitric OxideTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID37151606
PMCPMC10162877
OpenAlexW4367296483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.