Evidence map›Paper›PMID 37151508›Full record

ArticleACS omega2023

Chemoenzymatic Preparation of a

Amanda J Reid, Katelyn M Erickson, Joseph M Hazel, Vinita Lukose, Jerry M Troutman

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Stepwise Assembly of theBiochemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amanda J ReidNanoscale Science Program, University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, North Carolina 28223, United States.
Katelyn M EricksonNanoscale Science Program, University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, North Carolina 28223, United States.
Joseph M HazelDepartment of Chemistry, University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, North Carolina 28223, United States.
Vinita LukoseDepartments of Chemistry and Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Jerry M TroutmanNanoscale Science Program, University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, North Carolina 28223, United States.ORCID https://orcid.org/0000-0002-8340-462X
University of North Carolina at Charlotte · USMassachusetts Institute of Technology · US

Funding

In vitro and Cellular Tools for Complex Polysaccharide BiosynthesisR01GM123251 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI TROUTMAN, JERRY M · 2017 to 2023
$2.1M
Chemoenzymatic preparation of tagged bactoprenyl diphosphate linked sugar probes for in vitro and cellular elucidation of complex bacterial polysaccharidesF31GM130065 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI REID, AMANDA · 2018 to 2020
$101k
NIGMS NIH HHS F31 GM130065NIGMS NIH HHS R01 GM123251
6 · The paper itself

Abstract

Complex poly- and oligosaccharides on the surface of bacteria provide a unique fingerprint to different strains of pathogenic and symbiotic microbes that could be exploited for therapeutics or sensors selective for specific glycans. To discover reagents that can selectively interact with specific bacterial glycans, a system for both the chemoenzymatic preparation and immobilization of these materials would be ideal. Bacterial glycans are typically synthesized in nature on the C55 polyisoprenoid bactoprenyl (or undecaprenyl) phosphate. However, this long-chain isoprenoid can be difficult to work with in vitro. Here, we describe the addition of a chemically functional benzylazide tag to polyisoprenoids. We have found that both the organic-soluble and water-soluble benzylazide isoprenoid can serve as a substrate for the well-characterized system responsible for

Identifiers

PMID37151508
PMCPMC10157688
OpenAlexW4366758832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.