Evidence map›Paper›PMID 37151435›Full record

ArticleSurgical neurology international2023

Severe type of segmental spinal dysgenesis with complete disconnection of the spinal cord and vertebra associated with open neural tube defect.

Ai Kurogi, Nobuya Murakami, Takafumi Shimogawa, Nobutaka Mukae, Satoshi O Suzuki, Toru Yamaguchi, Koji Yoshimoto, Takato Morioka

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical neurology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ai KurogiDepartment of Neurosurgery, Fukuoka Children's Hospital, Fukuoka, Japan.
Nobuya MurakamiDepartment of Neurosurgery, Fukuoka Children's Hospital, Fukuoka, Japan.
Takafumi ShimogawaDepartment of Neurosurgery, Kyushu University, Fukuoka, Japan.
Nobutaka MukaeDepartment of Neurosurgery, Kyushu University, Fukuoka, Japan.
Satoshi O SuzukiDepartment of Psychiatry, Shourai Hospital, Fukuoka, Japan.
Toru YamaguchiDepartment of Orthopedic Surgery, Fukuoka Children's Hospital, Fukuoka, Japan.
Koji YoshimotoDepartment of Neurosurgery, Kyushu University, Fukuoka, Japan.
Takato MoriokaDepartment of Neurosurgery, Harasanshin Hospital, Fukuoka, Japan.
Fukuoka Children's Hospital and Medical Center for Infectious Diseases · JPKyushu University · JPHarasanshin Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Severe type of segmental spinal dysgenesis (SSD) is a rare and complex anomaly in which the spinal cord completely disconnects at the portion of the spinal dysgenesis. Although closed spinal dysraphisms have been associated with SSD, to the best of our knowledge, the association between open neural tube defect (ONTD) and SSD is significantly rare, with only one case being reported to date. Case Description: We report a case of an infant with severe SSD and a disconnected spinal cord and spinal column at the thoracolumbar junction associated with myelomeningocele (MMC) in the lumbosacral region. The patient presented severe neurological deficits in the legs and impaired bowel function. The spinal column of L1-L3 was absent. The lower spinal segment consisted of neural placode at the L5-S1 level and no connecting structure between the upper and lower spinal cords. A repair surgery for MMC, including cord untethering and dura plasty, was performed. Histopathological findings revealed a neural placode consisting of a neuroglial tissue and leptomeninges. Conclusion: The management of severe SSD during the perinatal period is more challenging when it is associated with ONTD. We report detailed neuroradiological, intraoperative, and histological findings of such a case and discuss the embryopathogenesis of the associated ONTD and the treatment strategies.

Indexed as

GastrulationJunctional neural tube defectNeurulation failureOpen neural tube defectSegmental spinal dysgenesis

Identifiers

PMID37151435
PMCPMC10159279
OpenAlexW4367298247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.