SynthesisBJS open2023
Quality of life in early-onset colorectal cancer patients: systematic review.
Synthesis in BJS open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Effect Size of Factors Influencing Colorectal Cancer Survivors' Quality of Life: A Systematic Review and Meta-Analysis.Cancer medicine · 2026Pooled it
- Prognostic impact of myosteatosis on postoperative outcomes and survival in colorectal cancer: a systematic review.International journal of colorectal disease · 2026Pooled it
- Trial
- Early-Onset Colorectal Cancer: Clinical and Molecular Features with Emerging Insights from Comprehensive Genomic Profiling.Oncology and therapy · 2026Review
- Effects of Telerehabilitation on Functional and Other Health-Related Outcomes in Colorectal Cancer Patients and Survivors: A Systematic Review and Meta-analysis.Archives of rehabilitation research and clinical translation · 2026Review
- Differences in quality of life between early onset colorectal cancer patients compared to older patients: a qualitative study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Oncofertility in gastrointestinal oncology: a pan-European study of the patient perspective.The oncologist · 2026Article
- Quality of life assessment for colorectal cancer follow-up: A latent profile analysis of EORTC measures.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Long-term disease-free survival in young-onset rectal cancer patients surgically treated with curative intent: a retrospective cohort study.International journal of colorectal disease · 2026Article
- A qualitative study of age-specific care needs in patients with early-onset advanced colorectal cancer.PEC innovation · 2026Article
- Structured pelvic floor physiotherapy rehabilitation for low anterior resection syndrome in colorectal cancer: An Australian feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Organ preservation with total neoadjuvant therapy in early-stage rectal cancer: A statewide analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Interaction between illness cognitions and dyadic coping: a qualitative exploration of stress adaptation in young and middle-aged colorectal cancer patients and their spouses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Clinical and molecular characteristics of early-onset pancreatic and biliary cancers.ESMO gastrointestinal oncology · 2026Review
- Prevalence and patterns of sexual dysfunctions among male cancer survivors: real-world evidence from a tertiary andrology centre.International journal of impotence research · 2026Article
- Acceptance of illness and its relationship with benefit finding among patients with colorectal cancer undergoing chemotherapy: A latent profile analysis.Asia-Pacific journal of oncology nursing · 2025Article
- Is the Incidence of Early-Onset Adenocarcinomas in Aotearoa New Zealand Increasing?Asia-Pacific journal of clinical oncology · 2025Article
- Predictors of impaired quality of life among colorectal cancer survivors: a cross-sectional study.Journal of patient-reported outcomes · 2025Article
- Early-onset gastrointestinal cancers: comprehensive review and future directions.The British journal of surgery · 2025Review
- Perceived economic pressure and health-related quality of life of patients with colorectal cancer after surgery: Evidence from China.Journal of family medicine and primary care · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an increasing incidence of early-onset colorectal cancer; however, the psychosocial impacts of this disease on younger adults have been seldom explored.
methodsA systematic review was conducted according to the PRISMA guidelines. The Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL, PubMed, and Scopus were searched, and papers were included if published in English within the last 10 years and if they reported results separately by age (including early-onset colorectal cancer, defined as colorectal cancer diagnosed before the age of 50 years). Critical appraisal of all studies was done using the Joanna Briggs Institute tools. The primary outcome of interest was the global quality of life in patients with early-onset colorectal cancer. Secondary outcomes included the effect on sexual function, body image, finances, career, emotional distress, and social and family functioning.
resultsThe search yielded 168 manuscripts and 15 papers were included in the review after screening. All studies were observational, and included a total of 18 146 patients, of which 5015 were patients with early-onset colorectal cancer. The studies included scored highly using Joanna Briggs Institute critical appraisal tools, indicating good quality and a low risk of bias, but data synthesis was not performed due to the wide range of scoring systems that were used across the studies. Six papers reported significant negative impacts on quality of life in patients with early-onset colorectal cancer. Three of the four studies that compared the quality of life in patients with early-onset colorectal cancer with older patients found that the younger group had worse mean quality-of-life scores (P ≤ 0.05). Secondary outcomes measured in five studies in relation to sexual dysfunction, body image, financial and career impacts, and social and family impacts and in eight studies in relation to emotional distress were found to be more severely impacted in those with early-onset colorectal cancer compared with those with late-onset colorectal cancer.
conclusionWhilst data are limited, the impact of colorectal cancer is different in patients with early-onset colorectal cancer compared with older patients in relation to several aspects of the quality of life. This is particularly prominent in areas of global quality of life, sexual functioning, family concerns, and financial impacts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.