ArticleJournal of neurochemistry2024
Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO
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Article in Journal of neurochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Lactate Changes Quantified by fMRS: A Meta-Analysis.NMR in biomedicine · 2026Pooled it
- Altering MRI rotating frame relaxations by changing the truncation level of Hyperbolic Secant pulse.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Age dependence of brain oxygen metabolism in adults assessed by 3D constrained quantitative BOLD MRI.NeuroImage · 2026Article
- Aerobic glycolysis in Schizophrenia: Developmental rescue or energetic breakdown?Molecular psychiatry · 2026Review
- BOLD signal changes can oppose oxygen metabolism across the human cortex.Nature neuroscience · 2026Article
- Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortex.Cell death and differentiation · 2026Article
- Microvascular network organization and hemodynamic perfusion protect the brain against hypoxia.bioRxiv : the preprint server for biology · 2026Article
- Associations between incremental exercise capacity and multimodal brain characteristics across training levels.Frontiers in human neuroscience · 2026Article
- Review
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Lactate Transport via Glial MCT1 and Neuronal MCT2 Is Not Required for Synchronized Synaptic Transmission in Hippocampal Slices Supplied With Glucose.Journal of neurochemistry · 2025Article
- A Bird's-Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons.Journal of neurochemistry · 2025Review
- A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep.Fluids and barriers of the CNS · 2025Review
- Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient.The Journal of membrane biology · 2025Article
- Reduced removal of waste products from energy metabolism takes center stage in human brain aging.Scientific reports · 2025Article
- The pathobiology of neurovascular aging.Neuron · 2025Review
- Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo.Neurochemical research · 2025Review
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture.Nature communications · 2024Article
- Brain energy metabolism: A roadmap for future research.Journal of neurochemistry · 2024Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Mauro DiNuzzoCentro Ricerche Enrico Fermi, Rome, Italy.ORCID 0000-0003-0181-5597
Gerald A DienelDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0001-8887-3057
Kevin L BeharDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-1467-0446
Ognen A PetroffDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-2841-1533
Helene BenvenisteDepartment of Anesthesiology, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-2887-6667
Fahmeed HyderDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-7822-4002
Federico GioveCentro Ricerche Enrico Fermi, Rome, Italy.ORCID 0000-0002-6934-3146
Shalom MichaeliDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-5426-8369
Silvia MangiaDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-6341-4516
Suzana Herculano-HouzelDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-1765-3599
Douglas L RothmanDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-9321-4195
Yale University · USCentro Ricerche Enrico Fermi · ITUniversity of Minnesota · USUniversity of New Mexico · USVanderbilt University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7MLinking Connectomics to Biochemical Trajectories of Aging: How the Human BrainAges Differentially in Key Regions of the Default Mode NetworkR01AG055591 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI MANGIA, SILVIA, TERPSTRA, MELISSA J · 2017 to 2021
$3.4MComputer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRIR01CA241159 · NCI · UNIVERSITY OF MINNESOTA · PI METZGER, GREGORY JOHN · 2021 to 2025
$3.0MIdentifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 DiabetesR01DK099137 · NIDDK · UNIVERSITY OF MINNESOTA · PI MANGIA, SILVIA · 2014 to 2018
$2.5M13C MRS Studies of Brain Mitochondrial Metabolism in Insulin ResistanceR01NS087568 · NINDS · YALE UNIVERSITY · PI PETERSEN, KITT F, ROTHMAN, DOUGLAS LYLE · 2014 to 2018
$2.1MValidation of GABA MRS as a Biomarker of InhibitionR01MH109159 · NIMH · YALE UNIVERSITY · PI BEHAR, KEVIN L, ROTHMAN, DOUGLAS LYLE · 2016 to 2019
$1.7MNext-Generation fMRI with MB-SWIFT: Insights into the Origins of ContrastR01MH127548 · NIMH · UNIVERSITY OF MINNESOTA · PI MANGIA, SILVIA, MICHAELI, SHALOM · 2021 to 2023
$1.6MMRS validation of computational metabolic modeling of human brain function to determine energetic disruptions underlying fMRI-derived functional connectivity in degenerative or psychiatric disordersR01NS100106 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED, ROTHMAN, DOUGLAS LYLE · 2017 to 2021
$959kBRAIN/GUT AXIS--METHODS TO EXAMINE PEPTIDE DYNAMICSF33DK009913 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEPHENS, ROBERT L · 1999 to 1999
–NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA241159NIA NIH HHS R01 AG055591NIBIB NIH HHS P41 EB027061NIDDK NIH HHS F33 DK009913NIDDK NIH HHS R01 DK099137NIH HHS R01 DK09913 (SMa)NIH HHS R01 MH109159 (DLR)NIH HHS R01 MH109159 (KLB)NIH HHS R01 MH127548 (SMa)NIH HHS R01 MH127548 (SMi)NIH HHS R01 NS087568 (DLR)NIH HHS R01 NS087568 (FH)NIH HHS R01 NS100106 (DLR)NIMH NIH HHS R01 MH109159NIMH NIH HHS R01 MH127548NINDS NIH HHS R01 NS087568NINDS NIH HHS R01 NS100106
Abstract
During transient brain activation cerebral blood flow (CBF) increases substantially more than cerebral metabolic rate of oxygen consumption (CMRO
Indexed as
BrainCarbon DioxideCerebrovascular CirculationGlycogenolysisGlycolysisHomeostasisNeurovascular CouplingProtonsHumansHydrogen-Ion ConcentrationMagnetic Resonance ImagingOxygenOxygen ConsumptionCarbon DioxideOxygenProtonsaerobic glycolysisbrain activationcerebral lactateglucose sparing by glycogenolysishomeostasisneurovascular coupling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.