ArticleEpilepsia2023
Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study.EBioMedicine · 2025Trial
- Distinct neural processes link speech planning and execution.Nature human behaviour · 2026Article
- Shared latent representations of speech production for cross-patient speech decoding.Nature communications · 2026Article
- An artefact-resilient wide bandwidth bidirectional graphene neural interface.Nature communications · 2026Article
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Mapping intraoperative interictal epileptiform discharges using high-resolution, thin-film cortical arrays.Epilepsia · 2026Article
- Distance of bipolar re-referencing imparts nonlinear frequency-specific influences on intracranial recording signal measurements.Journal of neural engineering · 2025Article
- PyHFO 2.0: an open-source platform for deep learning-based clinical high-frequency oscillations analysis.Journal of neural engineering · 2025Article
- Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation.Nature biomedical engineering · 2025Review
- Materials and devices for high-density, high-throughput micro-electrocorticography arrays.Fundamental research · 2025Review
- Comparison of Subdural and Intracortical Recordings of Somatosensory Evoked Responses.Sensors (Basel, Switzerland) · 2024Article
- Intan Technologies integrated circuits can produce analog-to-digital conversion artifacts that affect neural signal acquisition.Journal of neural engineering · 2024Article
- PyHFO: lightweight deep learning-powered end-to-end high-frequency oscillations analysis application.Journal of neural engineering · 2024Article
- Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation.Nature nanotechnology · 2024Article
- Multiplexed Surface Electrode Arrays Based on Metal Oxide Thin-Film Electronics for High-Resolution Cortical Mapping.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- High-resolution neural recordings improve the accuracy of speech decoding.Nature communications · 2023Article
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Authors and funding
26 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveEffective surgical treatment of drug-resistant epilepsy depends on accurate localization of the epileptogenic zone (EZ). High-frequency oscillations (HFOs) are potential biomarkers of the EZ. Previous research has shown that HFOs often occur within submillimeter areas of brain tissue and that the coarse spatial sampling of clinical intracranial electrode arrays may limit the accurate capture of HFO activity. In this study, we sought to characterize microscale HFO activity captured on thin, flexible microelectrocorticographic (μECoG) arrays, which provide high spatial resolution over large cortical surface areas.
methodsWe used novel liquid crystal polymer thin-film μECoG arrays (.76-1.72-mm intercontact spacing) to capture HFOs in eight intraoperative recordings from seven patients with epilepsy. We identified ripple (80-250 Hz) and fast ripple (250-600 Hz) HFOs using a common energy thresholding detection algorithm along with two stages of artifact rejection. We visualized microscale subregions of HFO activity using spatial maps of HFO rate, signal-to-noise ratio, and mean peak frequency. We quantified the spatial extent of HFO events by measuring covariance between detected HFOs and surrounding activity. We also compared HFO detection rates on microcontacts to simulated macrocontacts by spatially averaging data.
resultsWe found visually delineable subregions of elevated HFO activity within each μECoG recording. Forty-seven percent of HFOs occurred on single 200-μm-diameter recording contacts, with minimal high-frequency activity on surrounding contacts. Other HFO events occurred across multiple contacts simultaneously, with covarying activity most often limited to a .95-mm radius. Through spatial averaging, we estimated that macrocontacts with 2-3-mm diameter would only capture 44% of the HFOs detected in our μECoG recordings. SIGNIFICANCE: These results demonstrate that thin-film microcontact surface arrays with both highresolution and large coverage accurately capture microscale HFO activity and may improve the utility of HFOs to localize the EZ for treatment of drug-resistant epilepsy.
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