Evidence map›Paper›PMID 37150885›Full record

ArticleThe Journal of infectious diseases2023

Accumulation of Neutrophil Phagocytic Antibody Features Tracks With Naturally Acquired Immunity Against Malaria in Children.

Nadege Nziza, Tuan M Tran, Elizabeth A DeRiso, Sepideh Dolatshahi, Jonathan D Herman, Luna de Lacerda, Caroline Junqueira, Judy Lieberman, Aissata Ongoiba, Safiatou Doumbo and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Nadege NzizaRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Tuan M TranMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Elizabeth A DeRisoRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Sepideh DolatshahiRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Jonathan D HermanRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Luna de LacerdaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Caroline JunqueiraProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Judy LiebermanProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Aissata OngoibaMalaria Research and Training Centre, Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Safiatou DoumboMalaria Research and Training Centre, Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Kassoum KayentaoMalaria Research and Training Centre, Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Boubacar TraoreMalaria Research and Training Centre, Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Peter D CromptonMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Galit AlterRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Ragon Institute of MGH, MIT and Harvard · USUniversité des Sciences, des Techniques et des Technologies de Bamako · MLBoston Children's Hospital · USFundação Oswaldo Cruz · BRHarvard University · USIndiana University School of MedicineNational Institute of Allergy and Infectious Diseases · US

Funding

Mechanisms of naturally-acquired immunity to malaria and clinical trials of anti-malaria monoclonal antibodiesZIAAI001155 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CROMPTON, PETER · 2011 to 2025
$30.9M
Defining functional humoral correlates of immunity to guide vaccine designR01AI151178 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BATISTA, FACUNDO DAMIAN · 2021 to 2025
$4.0M
Defining clinical and sterile immunity to Plasmodium falciparum infection using systems biology approachesK08AI125682 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI TRAN, TUAN MANH · 2017 to 2021
$926k
Validation and characterization of antibody responses to Plasmodium falciparum antigens identified by protein array screeningR03AI159780 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI TRAN, TUAN MANH · 2021 to 2022
$159k
NIAID NIH HHS 5K08AI125682NIAID NIH HHS K08 AI125682NIAID NIH HHS R01 AI151178NIAID NIH HHS R03 AI159780
6 · The paper itself

Abstract

backgroundStudies have demonstrated the protective role of antibodies against malaria. Young children are known to be particularly vulnerable to malaria, pointing to the evolution of naturally acquired clinical immunity over time. However, whether changes in antibody functionality track with the acquisition of naturally acquired malaria immunity remains incompletely understood.

methodsUsing systems serology, we characterized sporozoite- and merozoite-specific antibody profiles of uninfected Malian children before the malaria season who differed in their ability to control parasitemia and fever following Plasmodium falciparum (Pf) infection. We then assessed the contributions of individual traits to overall clinical outcomes, focusing on the immunodominant sporozoite CSP and merozoite AMA1 and MSP1 antigens.

resultsHumoral immunity evolved with age, with an expansion of both magnitude and functional quality, particularly within blood-stage phagocytic antibody activity. Moreover, concerning clinical outcomes postinfection, protected children had higher antibody-dependent neutrophil activity along with higher levels of MSP1-specific IgG3 and IgA and CSP-specific IgG3 and IgG4 prior to the malaria season.

conclusionsThese data point to the natural evolution of functional humoral immunity to Pf with age and highlight particular antibody Fc-effector profiles associated with the control of malaria in children, providing clues for the design of next-generation vaccines or therapeutics.

Indexed as

MalariaMalaria, FalciparumAdaptive ImmunityAnimalsAntibodies, ProtozoanAntigens, ProtozoanAutoantibodiesChildChild, PreschoolHumansImmunoglobulin GMerozoitesMerozoite Surface Protein 1NeutrophilsPlasmodium falciparumAntibodies, ProtozoanAntigens, ProtozoanAutoantibodiesImmunoglobulin GMerozoite Surface Protein 1antibodieschildrenclinical immunitymalarianeutrophils

Identifiers

PMID37150885
PMCPMC10503956
OpenAlexW4367055707

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.