Evidence map›Paper›PMID 37150780›Full record

ArticleVirus genes2023

Whole genome sequencing and evolution analyses of Human metapneumovirus.

Tianli Wei, Chao Wang, Fenlian Ma, Jianqiang Guo, Aijun Chen, Yiman Huang, Zhiping Xie, Lishu Zheng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Article
  10. Review
  11. Minireview: Designing next generation human metapneumovirus (HMPV) vaccine.Clinical and experimental vaccine research · 2025
    Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tianli Wei *Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-An St., Xi-Cheng Dist., Beijing, 100050, China.
Chao Wang *NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, No. 100 Ying-Xin St., Xi-Cheng Dist., Beijing, 100052, China.
Fenlian MaNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, No. 100 Ying-Xin St., Xi-Cheng Dist., Beijing, 100052, China.
Jianqiang GuoNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, No. 100 Ying-Xin St., Xi-Cheng Dist., Beijing, 100052, China.
Aijun ChenNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, No. 100 Ying-Xin St., Xi-Cheng Dist., Beijing, 100052, China.
Yiman HuangNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, No. 100 Ying-Xin St., Xi-Cheng Dist., Beijing, 100052, China.
Zhiping XieNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, No. 100 Ying-Xin St., Xi-Cheng Dist., Beijing, 100052, China. xiezhiping@126.com.
Lishu ZhengNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, No. 100 Ying-Xin St., Xi-Cheng Dist., Beijing, 100052, China. zhengls@ivdc.chinacdc.cn.
Chinese Center For Disease Control and Prevention · CNCapital Medical University · CN

Funding

key technologies supporting the National Core Biological Resource Center, National Key R&D Program of China 2022YFC2602202
6 · The paper itself

Abstract

Human metapneumovirus (HMPV) is a major pathogen of acute respiratory tract infections (ARTIs) in children. Whole genome sequence analyses could help understand the evolution and transmission events of this virus. In this study, we sequenced HMPV whole genomes to improve the identification of molecular epidemiology in Beijing, China. Nasopharyngeal aspirates of hospitalized children aged < 14 years old with ARTIs were screened for HMPV infection using qPCR. Fourteen pairs of overlapping primers were used to amplify whole genome sequences of HMPV from positive samples with high viral loads. The epidemiology of HMPV was analysed and 27 HMPV whole genome sequences were obtained. Sequence identity and the positional entropy analyses showed that most regions of HMPV genome are conserved, whereas the G gene contained many variations. Phylogenetic analysis identified 25 HMPV sequences that belonged to a newly defined subtype A2b1; G gene sequences from 24 of these contained a 111-nucleotide duplication. HMPV is an important respiratory pathogen in paediatric patients. The new subtype A2b1 with a 111-nucleotide duplication has become predominate in Beijing, China.

Indexed as

MetapneumovirusParamyxoviridae InfectionsPhylogenyAdolescentChildChild, PreschoolEvolution, MolecularFemaleHumansInfantMaleWhole Genome SequencingGenetic diversityHuman metapneumovirusWhole genome sequence

Identifiers

PMID37150780
PMCPMC10164418
OpenAlexW4375856342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.