ArticleScientific reports2023
Resting-state oscillations reveal disturbed excitation-inhibition ratio in Alzheimer's disease patients.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Clinical markers of disease progression in the prodromal to overt alpha-synucleinopathy continuum.Brain : a journal of neurology · 2026Article
- Resting-state functional and spectral alterations underlying cognitive decline in biomarker-confirmed Alzheimer's disease: A systematic review.NeuroImage. Clinical · 2026Article
- The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Altered Scale-Free Dynamics of Spontaneous Brain Activity in Post-Traumatic Stress Disorder: Relationship to Impaired Functional Connectivity.Brain sciences · 2026Article
- Connectome-Guided Personalization of Optimal TDCS Intervention Selection in Alzheimer's Disease: A Modeling Study.eNeuro · 2026Article
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- Virtual brain and electroencephalography explain the variance of memory alterations in mild cognitive impairment.Alzheimer's research & therapy · 2026Article
- Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer's disease-related hyperexcitability and brain network dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Chronic two-photon microscopy reveals neuronal activity patterns in the cerebral cortex of an Alzheimer's disease mouse model.Biomedical optics express · 2026Article
- Concurrent Multimodal Imaging Demonstrates That EEG-Based Excitation/Inhibition Balance Reflects Glutamate and GABA Balance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Scale-Free Neurodynamics as Functional Fingerprint of Brain Regions.Bioengineering (Basel, Switzerland) · 2026Article
- A Framework Integrating Spiking Cortical Circuit Modeling and Simulation-Based Inference to Probe Biomarkers of Cortical Dysfunction in Alzheimer's Disease.Interdisciplinary sciences, computational life sciences · 2026Article
- Early aperiodic EEG changes in preclinical and prodromal Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- APOE4 and doxorubicin impair inhibitory interneuron function and homeostatic regulation in the entorhinal cortex.PloS one · 2026Article
- A meta-analysis of periodic and aperiodic electrophysiological features in Parkinson's disease.Brain communications · 2026Review
- Resting-State EEG Power and Aperiodic Activity in Individuals with Mild Cognitive Impairment and Cognitively Healthy Controls.Brain sciences · 2025Article
- The development of aperiodic neural activity in the human brain.Nature human behaviour · 2025Article
- Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer's disease.Science advances · 2025Article
- Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies.Nature communications · 2025Article
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10 authors.
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Abstract
An early disruption of neuronal excitation-inhibition (E-I) balance in preclinical animal models of Alzheimer's disease (AD) has been frequently reported, but is difficult to measure directly and non-invasively in humans. Here, we examined known and novel neurophysiological measures sensitive to E-I in patients across the AD continuum. Resting-state magnetoencephalography (MEG) data of 86 amyloid-biomarker-confirmed subjects across the AD continuum (17 patients diagnosed with subjective cognitive decline, 18 with mild cognitive impairment (MCI) and 51 with dementia due to probable AD (AD dementia)), 46 healthy elderly and 20 young control subjects were reconstructed to source-space. E-I balance was investigated by detrended fluctuation analysis (DFA), a functional E/I (fE/I) algorithm, and the aperiodic exponent of the power spectrum. We found a disrupted E-I ratio in AD dementia patients specifically, by a lower DFA, and a shift towards higher excitation, by a higher fE/I and a lower aperiodic exponent. Healthy subjects showed lower fE/I ratios (< 1.0) than reported in previous literature, not explained by age or choice of an arbitrary threshold parameter, which warrants caution in interpretation of fE/I results. Correlation analyses showed that a lower DFA (E-I imbalance) and a lower aperiodic exponent (more excitation) was associated with a worse cognitive score in AD dementia patients. In contrast, a higher DFA in the hippocampi of MCI patients was associated with a worse cognitive score. This MEG-study showed E-I imbalance, likely due to increased excitation, in AD dementia, but not in early stage AD patients. To accurately determine the direction of shift in E-I balance, validations of the currently used markers and additional in vivo markers of E-I are required.
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