Evidence map›Paper›PMID 37150064›Full record

ArticleWater research2023

Stability and WBE biomarkers possibility of 17 antiviral drugs in sewage and gravity sewers.

Jiaqi Wen, Lei Duan, Bin Wang, Qian Dong, Yanchen Liu, Jun Huang, Gang Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Water research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiaqi WenState Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Emerging Organic Contaminants Control, Beijing Laboratory for Environmental Frontier Technologies, China.
Lei DuanState Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Emerging Organic Contaminants Control, Beijing Laboratory for Environmental Frontier Technologies, China.
Bin WangState Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Emerging Organic Contaminants Control, Beijing Laboratory for Environmental Frontier Technologies, China.
Qian DongState Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
Yanchen LiuState Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
Jun HuangState Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Emerging Organic Contaminants Control, Beijing Laboratory for Environmental Frontier Technologies, China.
Gang YuState Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Emerging Organic Contaminants Control, Beijing Laboratory for Environmental Frontier Technologies, China; Advanced Interdisciplinary Institute of Environment and Ecology, Beijing Normal University at Zhuhai, 519087, China. Electronic address: gangyu@bnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wastewater-based epidemiology (WBE) is a promising technique for monitoring the rapidly increasing use of antiviral drugs during the COVID-19 pandemic. It is essential to evaluate the in-sewer stability of antiviral drugs in order to determine appropriate biomarkers. This study developed an analytical method for quantification of 17 typical antiviral drugs, and investigated the stability of target compounds in sewer through 4 laboratory-scale gravity sewer reactors. Nine antiviral drugs (lamivudine, acyclovir, amantadine, favipiravir, nevirapine, oseltamivir, ganciclovir, emtricitabine and telbivudine) were observed to be stable and recommended as appropriate biomarkers for WBE. As for the other 8 unstable drugs (abacavir, arbidol, ribavirin, zidovudine, ritonavir, lopinavir, remdesivir and efavirenz), their attenuation was driven by adsorption, biodegradation and diffusion. Moreover, reaction kinetics revealed that the effects of sediments and biofilms were regarded to be independent in gravity sewers, and the rate constants of removal by biofilms was directly proportional to the ratio of surface area against wastewater volume. The study highlighted the potential importance of flow velocity for compound stability, since an increased flow velocity significantly accelerated the removal of unstable biomarkers. In addition, a framework for graded evaluation of biomarker stability was proposed to provide reference for researchers to select suitable WBE biomarkers. Compared with current classification method, this framework considered the influences of residence time and different removal mechanisms, which additionally screened four antiviral drugs as viable WBE biomarkers. This is the first study to report the stability of antiviral drugs in gravity sewers.

Indexed as

COVID-19Water Pollutants, ChemicalAntiviral AgentsBiomarkersHumansPandemicsSewageWastewater-Based Epidemiological MonitoringAntiviral AgentsBiomarkersSewageWater Pollutants, ChemicalAntiviral drugsFlow velocitySewer sedimentsStabilityWastewater-based epidemiology

Identifiers

PMID37150064
PMCPMC10149109

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.