Evidence map›Paper›PMID 37149124›Full record

ArticleJournal of molecular and cellular cardiology2023

Cardiac Protein Kinase D1 ablation alters the myocytes β-adrenergic response.

Juliana Mira Hernandez, Christopher Y Ko, Avery R Mandel, Erin Y Shen, Sonya Baidar, Ashley R Christensen, Kim Hellgren, Stefano Morotti, Jody L Martin, Bence Hegyi and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Juliana Mira HernandezDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America; Research Group in Veterinary Medicine-GIVET, School of Veterinary Medicine, University Corporation Lasallista, Caldas, Antioquia, Colombia.
Christopher Y KoDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America.
Avery R MandelDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America.
Erin Y ShenDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America.
Sonya BaidarDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America.
Ashley R ChristensenDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America.
Kim HellgrenDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America.
Stefano MorottiDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America.
Jody L MartinDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America; Cardiovascular Research Institute, University of California, Davis, Davis, CA 95616, United States of America.
Bence HegyiDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America.
Julie BossuytDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America. Electronic address: jbossuyt@ucdavis.edu.
Donald M BersDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, United States of America. Electronic address: dmbers@ucdavis.edu.
University of California, Davis · US

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
Modeling of subcellular signaling crosstalk in failing myocytesR00HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2020 to 2022
$722k
Modeling of subcellular signaling crosstalk in failing myocytesK99HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2018 to 2019
$237k
NHLBI NIH HHS K99 HL138160NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R00 HL138160NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL142282
6 · The paper itself

Abstract

β-adrenergic (β-AR) signaling is essential for the adaptation of the heart to exercise and stress. Chronic stress leads to the activation of Ca

Indexed as

Adrenergic AgentsAdrenergic beta-AgonistsMyocytes, CardiacProtein Kinase CAnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingMiceMice, KnockoutPhosphorylationRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumAdrenergic AgentsAdrenergic beta-AgonistsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Protein Kinase CRyanodine Receptor Calcium Release ChannelCa(2+) sparksCalcium handlingEC-couplingProtein kinase DRyanodine receptorβ-Adrenergic stimulation

Identifiers

PMID37149124
PMCPMC11186477
OpenAlexW4368363194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.