Evidence map›Paper›PMID 37148999›Full record

ArticleContemporary clinical trials2023

Adaptive interventions for alcohol misuse and violent behaviors among adolescents and emerging adults in the emergency department: A sequential multiple assignment randomized controlled trial protocol.

Maureen A Walton, Patrick M Carter, Laura Seewald, Quyen Ngo, Katherine A Battisti, Claire Pearson, Frederic C Blow, Rebecca M Cunningham, Carrie Bourque, Kelley M Kidwell

Open access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Maureen A WaltonInjury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA; Addiction Center, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA. Electronic address: waltonma@med.umich.edu.
Patrick M CarterInjury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA; Department of Emergency Medicine, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd Bldg 10-G080, Ann Arbor, MI 48109-2800, USA.
Laura SeewaldInjury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA; Department of Emergency Medicine, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd Bldg 10-G080, Ann Arbor, MI 48109-2800, USA.
Quyen NgoHazelden Betty Ford Foundation, 15251 Pleasant Valley Road, Center City, MN 55012, USA.
Katherine A BattistiDepartment of Pediatrics, Central Michigan University and Covenant Hospital, Saginaw, MI 48602, USA.
Claire PearsonWayne State University, Department of Emergency Medicine, and St. John Hospital, Detroit, MI 48109, USA.
Frederic C BlowAddiction Center, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Rebecca M CunninghamInjury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA; Department of Emergency Medicine, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd Bldg 10-G080, Ann Arbor, MI 48109-2800, USA.
Carrie BourqueAddiction Center, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Kelley M KidwellDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan–Ann Arbor · USCentral Michigan University · USFord Foundation · USWayne State University · US

Funding

Adaptive Interventions to Reduce Risky Drinking and Violent Behaviors among AdolescentsR01AA024755 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTON, MAUREEN A · 2016 to 2020
$2.9M
Firearm Safety Among Children and Teens (FACTS): Multi-Disciplinary Research Training ProgramT32HD108054 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Patrick M. Carter, Marc A Zimmerman · 2022 to 2026
$1.7M
NIAAA NIH HHS R01 AA024755NICHD NIH HHS T32 HD108054
6 · The paper itself

Abstract

Alcohol use and violent behaviors among youth are associated with morbidity and mortality. An emergency department (ED) visit provides an opportunity to initiate prevention efforts. Despite promising findings from our single session SafERteens brief intervention (BI), impact is limited by modest effect sizes, with data lacking on optimal boosters to enhance effects. This paper describes the protocol for a sequential, multiple assignment, randomized trial (SMART). Adolescents and emerging adults (ages 14-20) in the ED screening positive for alcohol use and violent behaviors (physical aggression) were randomly assigned to: 1) SafERteens BI + Text Messaging (TM), or 2) SafERteens BI + remote Health Coach (HC). Participants completed weekly surveys over 8 weeks after the ED visit to tailor intervention content and measure mechanisms of change. At one-month, intervention response/non-response is determined (e.g., binge drinking or violent behaviors). Responders are re-randomized to continued intervention condition (e.g., maintenance) or minimized condition (e.g., stepped down). Non-responders are re-randomized to continued condition (e.g., maintenance), or intensified condition (e.g., stepped up). Outcomes were measured at 4 and 8 months, including primary outcomes of alcohol consumption and violence, with secondary outcomes of alcohol consequences and violence consequences. Although the original goal was to enroll 700 participants, COVID-19 impacts on research diminished recruitment in this trial (enrolled n = 400). Nonetheless, the proposed SMART is highly innovative by blending real-time assessment methodologies with adaptive intervention delivery among teens with comorbid alcohol misuse and violent behaviors. Findings will inform the content and timing booster interventions to alter risk behavior trajectories. Trial Registration:ClinicalTrials.govNCT03344666. University of Michigan # HUM00109156.

Indexed as

Adolescent BehaviorAlcoholismCOVID-19AdolescentAggressionAlcohol DrinkingEmergency Service, HospitalHumansRandomized Controlled Trials as TopicYoung AdultAggressionAlcohol misuseInterventionViolent behaviorsYouth

Identifiers

PMID37148999
PMCPMC10947472
OpenAlexW4368340976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.