Evidence map›Paper›PMID 37148943›Full record

ArticleInternational journal of biological macromolecules2023

Design of novel pyrimidine based remdesivir analogues with dual target specificity for SARS CoV-2: A computational approach.

T V Dinesh, Beutline Malgija, Mano Ranjana Ponraj, Pavankumar Muralakar, Jesse Joel Thathapudi, Ruckmani Kandasamy, Jeyasankar Alagarmalai, Anna Benedict Balakrishnan, Perumal Samy Ramar, Jannet Vennila James and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological macromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

T V DineshMedicinal Organic Chemistry Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamilnadu, India.
Beutline MalgijaComputational Science Laboratory, MCC-MRF Innovation Park, Madras Christian College, Chennai 600059, Tamilnadu, India.
Mano Ranjana PonrajMedicinal Organic Chemistry Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamilnadu, India.
Pavankumar MuralakarMedicinal Organic Chemistry Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamilnadu, India.
Jesse Joel ThathapudiDepartment of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamilnadu, India.
Ruckmani KandasamyDepartment of Pharmaceutical Technology, Centre for Nanobio Translational Research (CENTRE) Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, India.
Jeyasankar AlagarmalaiDepartment of Zoology, Government Arts College, Coimbatore, Tamilnadu, India.
Anna Benedict BalakrishnanDepartment of Chemistry, Panimalar Engineering College, Chennai 600123, Tamilnadu, India.
Perumal Samy RamarDepartment of Anatomy, 4 Medical Drive, MD10, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System (NUHS), Singapore 117594, Singapore.
Jannet Vennila JamesComputational Science Laboratory, MCC-MRF Innovation Park, Madras Christian College, Chennai 600059, Tamilnadu, India. Electronic address: jannetvennila@gmail.com.
Jebasingh BhagavathsinghMedicinal Organic Chemistry Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamilnadu, India; HPLC MASS Facility, Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamilnadu, India. Electronic address: jebasinghb@karunya.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the world undergone unpreceded time of tragedy with the corona virus, many researchers have raised to showcase their scientific contributions in terms of novel configured anti-viral drugs until now. Herein, we designed pyrimidine based nucleotides and assessed for the binding capability with SARS-CoV-2 viral replication targets of nsp12 RNA-dependent RNA polymerase and M

Indexed as

COVID-19SARS-CoV-2Adenosine MonophosphateAlanineAntiviral AgentsCOVID-19 Drug TreatmentHumansMolecular Docking SimulationMolecular Dynamics SimulationPyrimidinesRNA-Dependent RNA PolymeraseAdenosine MonophosphateAlanineAntiviral AgentsPyrimidinesremdesivirRNA-Dependent RNA PolymeraseCorona virusCovalent dockingCOVID-19Main proteaseMolecular dynamics simulationsMolecular modellingPyrimidine based remdesivir analoguesRNA-dependent DNA polymeraseSARS CoV-2

Identifiers

PMID37148943
PMCPMC10158044

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.