Observational studyThe Journal of allergy and clinical immunology2023
An eosinophil peroxidase activity assay accurately predicts eosinophilic chronic rhinosinusitis.
Observational study in The Journal of allergy and clinical immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Predictive value of blood eosinophil count and serum total immunoglobulin E for type 2 chronic rhinosinusitis according to allergic sensitization status.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Eosinophil Peroxidase as a Dynamic Indicator of Treatment Response in Eosinophilic Chronic Rhinosinusitis.International forum of allergy & rhinology · 2026Article
- In office sampling of eosinophil peroxidase to diagnose eosinophilic chronic rhinosinusitis.International forum of allergy & rhinology · 2025Article
- An eosinophil peroxidase activity assay predicts acute exacerbations in post-operative chronic rhinosinusitis.International forum of allergy & rhinology · 2024Article
- Predictive modeling for eosinophilic chronic rhinosinusitis: Nomogram and four machine learning approaches.iScience · 2024Article
- Association between peripheral eosinophilia, JESREC score, and olfactory dysfunction in patients with chronic rhinosinusitis.Frontiers in immunology · 2024Article
- Chemokine CCL19 and Its Receptors CCR7 and CCRL1 in Chronic Rhinosinusitis.Journal of inflammation research · 2024Article
- Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA definitive diagnosis of eosinophilic chronic rhinosinusitis (eCRS) requires invasive surgical tissue sampling and histologic enumeration of intact eosinophils. Eosinophil peroxidase (EPX) is an accurate biomarker of sinonasal tissue eosinophilia in CRS regardless of polyp status. A less invasive and rapid method that accurately identifies tissue eosinophilia would be of great benefit to patients.
objectiveWe sought to evaluate a new clinical tool that uses a nasal swab and colorimetric EPX activity assay to predict a diagnosis of eCRS.
methodsA prospective, observational cohort study was conducted using nasal swabs and sinonasal tissue biopsies obtained from patients with CRS electing endoscopic sinus surgery. Patients were classified as non-eCRS (n = 19) and eCRS (n = 35) on the basis of pathologically determined eosinophil counts of less than 10 or greater than or equal to 10 eosinophils/HPF, respectively. Swab-deposited EPX activity was measured and compared with tissue eosinophil counts, EPX levels, and CRS-specific disease metrics.
resultsEPX activity was significantly increased in patients with eCRS than in patients without eCRS (P < .0001). With a relative absorbance unit cutoff value of greater than or equal to 0.80, the assay demonstrated high sensitivity (85.7%) and moderate specificity (79.0%) for confirming eCRS. Spearman correlations between EPX activity and tissue eosinophil counts (r
conclusionsThis investigation evaluates a nasal swab sampling method and EPX activity assay that accurately confirms eCRS. This method could potentially address the unmet need to identify sinonasal tissue eosinophilia at the point-of-care, as well as to longitudinally monitor eosinophil activity and treatment response.
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