Evidence map›Paper›PMID 37148403›Full record

ArticleBiological trace element research2024

A Two-Generation Reproductive Toxicity Study of Cerium Nitrate in Sprague-Dawley Rats.

Lijun Ren, Wenjing Shi, Yijun Tian, Tiantian Zhang, Jingjing Fang, Bin Zhang, Bijiang Geng, Jingjing Mao, Haoneng Wang, Jiqianzhu Zhang and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Lijun Ren *Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Wenjing Shi *Department of Naval Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University of the People's Liberation Army, Shanghai, 200433, China.
Yijun Tian *Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Tiantian ZhangSchool of Basic Medicine, Anhui Medical University, Anhui, 230032, China.
Jingjing FangNavy Medical Center of PLA, Naval Medical University of the People's Liberation Army, Shanghai, 200433, China.
Bin ZhangDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Bijiang GengDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Jingjing MaoDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Haoneng WangDepartment of Marine Radiation Medicine, Faculty of Naval Medicine, Naval Medical University of the People's Liberation Army, Shanghai, 200433, China.
Jiqianzhu ZhangDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Xiaoyu DaiDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Jifeng LiDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Xiaofang ZhangDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Jikuai ChenDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China. cjkmark@smmu.edu.cn.
Jiangbo ZhuDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China. jiangbozhu1@smmu.edu.cn.
Lang YanDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China. langyan@smmu.edu.cn.
Naval University of Engineering · CNAnhui Medical University · CNSecond Military Medical University · CN

Funding

Innovation Action Plan of Shanghai Science and Technology 20140900700National Natural Science Foundation of China 82173649National Natural Science Foundation of China 82173908Social Development Science and Technology research project of Shanghai 21dz1200302 ， 20dz1200102Strengthening basic disciplines plan 21 M0902
6 · The paper itself

Abstract

A two-generation reproductive toxicity study was performed to evaluate the effects of cerium nitrate on the development of the parent, offspring, and third generation of Sprague-Dawley (SD) rats. A total of 240 SD rats (30 rats/sex/group) were randomly divided into four dosage groups according to body weight: 0 mg/kg, 30 mg/kg, 90 mg/kg, and 270 mg/kg. The rats were administered different dosages of cerium nitrate by oral gavage. There were no observed changes related to cerium nitrate in body weight, food consumption, sperm survival rate, motility, mating rate, conception rate, abortion rate, uterine plus fetal weight, uterine weight, corpus luteum number, implantation rate, live fetus number (rate), stillbirth number (rate), absorbed fetus number (rate), appearance, visceral, and skeletal in rats of each generation dosage group. In addition, the pathological findings showed no significant lesions associated with cerium nitrate toxicity in all tissues and organs, including reproductive organs. In conclusion, the present study showed that long-term oral gavage of cerium nitrate at 30 mg/kg, 90 mg/kg, and 270 mg/kg had no significant effect on reproduction and the developmental ability of their offspring in rats. The no-observed-adverse-effect level (NOAEL) of cerium nitrate in SD rats was higher than 270 mg/kg.

Indexed as

ReproductionSemenAdministration, OralAnimalsBody WeightCeriumFemaleMalePregnancyRatsRats, Sprague-DawleyCeriumcerium nitrateCerium nitrateRatReproductive toxicityTwo-generation

Identifiers

PMID37148403
OpenAlexW4372358196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.