Evidence map›Paper›PMID 37148344›Full record

ReviewBiotechnology letters2023

Potential of Mortierellaceae for polyunsaturated fatty acids production: mini review.

Rafaela B Oliveira, Diogo Robl, Jaciane L Ienczak

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biotechnology letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rafaela B OliveiraDepartment of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianopolis, Brazil.
Diogo RoblDepartment of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, Brazil.
Jaciane L IenczakDepartment of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianopolis, Brazil. jaciane.ienczak@ufsc.br.ORCID http://orcid.org/0000-0003-4087-8339
Universidade Federal de Santa Catarina · BR

Funding

Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina 00000294/2020
6 · The paper itself

Abstract

The health benefits of polyunsaturated fatty acids (PUFAs) have encouraged the search for rich sources of these compounds. However, the supply chain of PUFAs from animals and plants presents environmental concerns, such as water pollution, deforestation, animal exploitation and interference in the trophic chain. In this way, a viable alternative has been found in microbial sources, mainly in single cell oil (SCO) production by yeast and filamentous fungi. Mortierellaceae is a filamentous fungal family world-renowned for PUFA-producing strains. For example, Mortierella alpina can be highlighted due to be industrially applied to produce arachidonic acid (20:4 n6), an important component of infant supplement formulas. Thus, the state of the art of strategies to increase PUFAs production by Mortierellaceae strains is presented in this review. Firstly, we have discussed main phylogenetic and biochemical characteristics of these strains for lipid production. Next, strategies based on physiological manipulation, using different carbon and nitrogen sources, temperature, pH and cultivation methods, which can increase PUFA production by optimizing process parameters are presented. Furthermore, it is possible to use metabolic engineering tools, controlling the supply of NADPH and co-factors, and directing the activity of desaturases and elongase to the target PUFA. Thus, this review aims to discuss the functionality and applicability of each of these strategies, in order to support future research for PUFA production by Mortierellaceae species.

Indexed as

Fatty Acids, UnsaturatedMortierellaAnimalsCarbonFatty AcidsMetabolic EngineeringPhylogenySaccharomyces cerevisiaeCarbonFatty AcidsFatty Acids, UnsaturatedArachidonic acidLipid biosynthesisMortierella alpinaMortierellaceaeSingle cell oil

Identifiers

PMID37148344
OpenAlexW4372358115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.