Evidence map›Paper›PMID 37148124›Full record

ArticleCartilage2024

Chondrocyte Viability of Particulated Porcine Articular Cartilage Is Maintained in Tissue Storage After Cryoprotectant Exposure, Vitrification, and Tissue Warming.

Mary Crisol, Kezhou Wu, Barry Congdon, Tamara D Skene-Arnold, Leila Laouar, Janet A W Elliott, Nadr M Jomha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mary CrisolDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-2738-8098
Kezhou WuDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-4452-2153
Barry CongdonDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Tamara D Skene-ArnoldDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Leila LaouarDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Janet A W ElliottDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-7883-3243
Nadr M JomhaDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveVitrification of articular cartilage (AC) is a promising technique which may enable long-term tissue banking of AC allografts. We previously developed a 2-step, dual-temperature, multi-cryoprotectant agent (CPA) loading protocol to cryopreserve particulated AC (1 mm

designThree experimental groups were examined at 5 time points: a fresh control (only incubated in medium), a vitrified - AA group, and a vitrified + AA group (

resultsThere was a mild decline in cell viability but both treatment groups maintained a viability of greater than 80% viable cells which is acceptable for clinical translation.

conclusionWe determined that particulated AC can be stored for up to 7 days after successful vitrification without a clinically significant decline in chondrocyte viability. This information can be used to guide tissue banks regarding the implementation of AC vitrification to increase cartilage allograft availability.

Indexed as

Ascorbic AcidCartilage, ArticularCell SurvivalChondrocytesCryopreservationCryoprotective AgentsVitrificationAnimalsSwineTissue PreservationAscorbic AcidCryoprotective Agentsarticular cartilageascorbic acidcryoprotective agentshypothermic storagevitrification

Identifiers

PMID37148124
PMCPMC11368895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.