ArticleCardiovascular ultrasound2023
Peak left atrial longitudinal strain is associated with all-cause mortality in patients with ventricular functional mitral regurgitation.
Article in Cardiovascular ultrasound, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Pooled it
- Left atrial reservoir strain by speckle-tracking echocardiography predicts prognosis in secondary mitral valve insufficiency.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Article
- Association of left atrial strain and fibrin clot properties in patients with heart failure and severe mitral regurgitation undergoing transcatheter edge-to-edge repair.Journal of thrombosis and thrombolysis · 2026Article
- Article
- Prognostic Implications of Guideline-Directed Medical Therapy for Heart Failure in Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Left atrial dysfunction relates to symptom onset in patients affected by severe degenerative mitral regurgitation.Cardiovascular ultrasound · 2024Article
- Current and Clinically Relevant Echocardiographic Parameters to Analyze Left Atrial Function.Journal of cardiovascular development and disease · 2024Review
- Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography.Heart failure reviews · 2024Review
- Left Atrium: A New Prognostic Marker and Therapeutic Target in Secondary Mitral Regurgitation?European cardiology · 2024Review
- Parameters of the mitral apparatus in patients with ischemic and nonischemic dilated cardiomyopathy.The Journal of international medical research · 2023Review
- Contemporary Echocardiographic Evaluation of Mitral Regurgitation and Guidance for Percutaneous Mitral Valve Repair.Journal of clinical medicine · 2023Review
- Potential Diagnostic and Prognostic Values of Left Atrial Strain in Valvular Heart Disease.Journal of cardiovascular echographyReview
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChronic mitral regurgitation promotes left atrial (LA) remodeling. However, the significance of LA dysfunction in the setting of ventricular functional mitral regurgitation (FMR) has not been fully investigated. Our aim was to assess the prognostic impact of peak atrial longitudinal strain (PALS), a surrogate of LA function, in patients with FMR and reduced left ventricular ejection fraction (LVEF).
methodsPatients with at least mild ventricular FMR and LVEF < 50% under optimized medical therapy who underwent transthoracic echocardiography at a single center were retrospectively identified in the laboratory database. PALS was assessed by 2D speckle tracking in the apical 4-chamber view and the study population was divided in two groups according to the best cut-off value of PALS, using receiver operating characteristics (ROC) curve analysis. The primary endpoint-point was all-cause mortality.
resultsA total of 307 patients (median age 70 years, 77% male) were included. Median LVEF was 35% (IQR: 27 - 40%) and median effective regurgitant orifice area (EROA) was 15mm
conclusionPALS is independently associated with all-cause mortality in patients with reduced LVEF and ventricular FMR.
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