Evidence map›Paper›PMID 37147520›Full record

ArticleJournal of neurology2023

Equating norms between the ALS Cognitive Behavioral Screen (ALS-CBS™) and the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in non-demented ALS patients.

Edoardo Nicolò Aiello, Federica Solca, Lucia Catherine Greco, Silvia Torre, Laura Carelli, Claudia Morelli, Alberto Doretti, Eleonora Colombo, Stefano Messina, Debora Pain and 14 more

Abstract read
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In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Validation of the Italian version of the In-Person Telephone Interview for Cognitive Status (IP-TICS).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Edoardo Nicolò Aiello *Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Federica Solca *Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Lucia Catherine GrecoNeuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy.
Silvia TorreDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Laura CarelliDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Claudia MorelliDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Alberto DorettiDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Eleonora ColomboDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Stefano MessinaDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Debora PainIstituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department of Milan Institute, Milan, Italy.
Alice RadiciIstituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department of Milan Institute, Milan, Italy.
Andrea LizioNeuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy.
Jacopo CasiraghiNeuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy.
Federica CerriNeuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy.
Susan WoolleySyneos Health, Morrisville, NC, USA.
Jennifer MurphyBiogen, Cambridge, MA, USA.
Lucio TremolizzoSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Ildebrando AppollonioSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Federico VerdeDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Valeria Ada SansoneNeuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy.
Christian LunettaIstituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department of Milan Institute, Milan, Italy.
Vincenzo SilaniDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Nicola Ticozzi *Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy.
Barbara Poletti *Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, MI, Italy. b.poletti@auxologico.it.ORCID http://orcid.org/0000-0003-4398-2051

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present study aimed at deriving equating norms to estimate scores on the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) based on those on the ALS Cognitive Behavioral Screen (ALS-CBS™) in an Italian cohort of non-demented ALS patients.

methodsALS-CBS™ and ECAS scores of 293 ALS patients without frontotemporal dementia were retrospectively retrieved. Concurrent validity of the ALS-CBS™ towards the ECAS was tested by covarying for demographics, disease duration and severity, presence of C9orf72 hexanucleotide repeat expansion and behavioural features. A linear-smoothing equipercentile equating (LSEE) model was employed to derive ALS-CBS™-to-ECAS cross-walks. Gaps in LSEE-based estimation were managed via a linear regression-based equating approach. Equivalence between empirical and derived ECAS scores was tested via a two-one-sided test (TOST) procedure for the dependent sample.

resultsThe ALS-CBS™ predicted the ECAS (β = 0.75), accounting for the vast majority of its variance (60% out of an R DISCUSSION: Italian practitioners and researchers have been herewith provided with valid, straightforward cross-walks to estimate the ECAS based on ALS-CBS™ scores in non-demented ALS patients. Conversions herewith provided will help avoid cross-sectional/longitudinal inconsistencies in test adoption within research, and possibly clinical, settings.

Indexed as

Amyotrophic Lateral SclerosisCognition DisordersCognitionCross-Sectional StudiesHumansNeuropsychological TestsRetrospective StudiesALS Cognitive Behavioral ScreenAmyotrophic lateral sclerosisEdinburgh Cognitive and Behavioural ALS ScreenEquatingFrontotemporal degeneration

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.