Evidence map›Paper›PMID 37147518›Full record

ArticleScientific reports2023

Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2.

Heba I Ghamry, Amany Belal, Mohamed Kandeel El-Ashrey, Haytham O Tawfik, Reem I Alsantali, Ahmad J Obaidullah, Ahmed A El-Mansi, Doaa Abdelrahman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Heba I GhamryNutrition and Food Sciences, Department of Home Economics, College of Home Economics, King Khalid University, P.O. Box 960, Abha, 61421, Saudi Arabia.
Amany BelalDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia. a.belal@tu.edu.sa.
Mohamed Kandeel El-AshreyPharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Elini St., Cairo, 11562, Egypt.
Haytham O TawfikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.
Reem I AlsantaliDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Ahmad J ObaidullahDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Ahmed A El-MansiBiology Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia.
Doaa AbdelrahmanDepartment of Clinical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Taif University · SACairo University · EGKing Khalid University · SAKing Saud University · SAMansoura University · EGPrincess Nourah bint Abdulrahman University · SATanta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Researchers are constantly searching for drugs to combat the coronavirus pandemic caused by SARS-CoV-2, which has lasted for over two years. Natural compounds such as phenolic acids are being tested against Mpro and AAK1, which are key players in the SARS-CoV-2 life cycle. This research work aims to study the ability of a panel of natural phenolic acids to inhibit the virus's multiplication directly through Mpro and indirectly by affecting the adaptor-associated protein kinase-1 (AAK1). Pharmacophore mapping, molecular docking, and dynamic studies were conducted over 50 ns and 100 ns on a panel of 39 natural phenolic acids. Rosmarinic acid (16) on the Mpro receptor (- 16.33 kcal/mol) and tannic acid (17) on the AAK1 receptor (- 17.15 kcal/mol) exhibited the best docking energy against both receptors. These favourable docking score values were found to be superior to those of the co-crystallized ligands. Preclinical and clinical research is required before using them simultaneously to halt the COVID-19 life cycle in a synergistic manner.

Indexed as

Coronavirus 3C ProteasesCOVID-19Protease InhibitorsAdaptor Proteins, Signal TransducingHumansHydroxybenzoatesMolecular Docking SimulationMolecular Dynamics SimulationOligonucleotidesProtein Serine-Threonine KinasesSARS-CoV-23C-like proteinase, SARS-CoV-2AAK1 protein, humanAdaptor Proteins, Signal TransducingCoronavirus 3C ProteasesHydroxybenzoatesOligonucleotidesphenolic acidProtease InhibitorsProtein Serine-Threonine Kinases

Identifiers

PMID37147518
PMCPMC10162004
OpenAlexW4372284293

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.