ArticleCommunications biology2023
Dynamic proteome trade-offs regulate bacterial cell size and growth in fluctuating nutrient environments.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Coarse-grained resource allocation modeling for decoding and rewiring microbial metabolism.Trends in microbiology · 2026Review
- A proteome optimal allocation model for elucidating effects of temperature on bacterial growth.NPJ systems biology and applications · 2026Article
- Inferring bacterial cell size dynamics across media conditions.Scientific reports · 2026Article
- Temperature-Dependent Regulation of Co-Occurring Toxins, Odor Compounds, and Disinfection By-Product Precursors in Two Bloom-Forming Species.Life (Basel, Switzerland) · 2025Article
- Medium dependent factors govern the functionality of engineered type III secretion systems.Journal of biological engineering · 2025Article
- Article
- Reinforcement learning for adaptive control of phenotypically heterogeneous bacterial populations.bioRxiv : the preprint server for biology · 2025Article
- Bacterial Proteomics and Antibiotic Resistance Identification: Is Single-Cell Analysis a Worthwhile Pursuit?Pathogens (Basel, Switzerland) · 2025Review
- Gene expression cycles drive non-exponential bacterial growth.Physical review research · 2025Article
- Cell Geometry Limits Bacterial Metabolic Efficiency.bioRxiv : the preprint server for biology · 2025Article
- Bacterial cell size modulation along the growth curve across nutrient conditions.bioRxiv : the preprint server for biology · 2024Article
- Article
- Shaping of microbial phenotypes by trade-offs.Nature communications · 2024Review
- Gene expression tradeoffs determine bacterial survival and adaptation to antibiotic stress.bioRxiv : the preprint server for biology · 2024Article
- Energy allocation theory for bacterial growth control in and out of steady state.bioRxiv : the preprint server for biology · 2024Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bacteria dynamically regulate cell size and growth to thrive in changing environments. While previous studies have characterized bacterial growth physiology at steady-state, a quantitative understanding of bacterial physiology in time-varying environments is lacking. Here we develop a quantitative theory connecting bacterial growth and division rates to proteome allocation in time-varying nutrient environments. In such environments, cell size and growth are regulated by trade-offs between prioritization of biomass accumulation or division, resulting in decoupling of single-cell growth rate from population growth rate. Specifically, bacteria transiently prioritize biomass accumulation over production of division machinery during nutrient upshifts, while prioritizing division over growth during downshifts. When subjected to pulsatile nutrient concentration, we find that bacteria exhibit a transient memory of previous metabolic states due to the slow dynamics of proteome reallocation. This allows for faster adaptation to previously seen environments and results in division control which is dependent on the time-profile of fluctuations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.