Evidence map›Paper›PMID 37147439›Full record

ArticlePediatric research2026

The influence of nutrition on white matter development in preterm infants: a scoping review.

Els Janson, Marle F Willemsen, Pauline E Van Beek, Jeroen Dudink, Ruurd M Van Elburg, Lisa M Hortensius, Emily W Y Tam, Miguel Saenz de Pipaon, Alexandre Lapillonne, Caroline G M de Theije and 3 more

Open access · greenAbstract readScoping Review
PubMed Publisher
In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Factors Influencing Breastfeeding Outcomes Following Neonatal Hypoxic Ischaemic Encephalopathy: A Mixed Methods Systematic Review.Journal of human lactation : official journal of International Lactation Consultant Association · 2026
    Pooled it
  2. Pregnancy diet based on ancestral patterns increases growth in subcortical fetal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 7 countries.

Els JansonDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Marle F WillemsenDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Pauline E Van BeekDepartment of Neonatology, Máxima Medical Center, Veldhoven, The Netherlands.
Jeroen DudinkDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Ruurd M Van ElburgDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Lisa M HortensiusDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Emily W Y TamDepartment of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Miguel Saenz de PipaonNeonatology, Instituto de Investigación Sanitaria, La Paz University Hospital-IdiPAZ (Universidad Autonoma), Madrid, Spain.
Alexandre LapillonneDepartment of Neonatology, Necker-Enfants Malades Hospital, University of Paris, Paris, France.
Caroline G M de TheijeDepartment for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, 3508 AB, Utrecht, The Netherlands.
Manon J N L BendersDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Niek E van der AaDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. N.vanderAa@umcutrecht.nl.
ESPR Nutrition council members
University Medical Center Utrecht · NLUtrecht University · NLMáxima Medisch Centrum · NLMcMaster University · CANIHR Southampton Biomedical Research Centre · GBOdense University Hospital · DKOslo University Hospital · NOUniversité Paris Cité · FRUniversity of Toronto · CAWilhelmina Children's Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White matter (WM) injury is the most common type of brain injury in preterm infants and is associated with impaired neurodevelopmental outcome (NDO). Currently, there are no treatments for WM injury, but optimal nutrition during early preterm life may support WM development. The main aim of this scoping review was to assess the influence of early postnatal nutrition on WM development in preterm infants. Searches were performed in PubMed, EMBASE, and COCHRANE on September 2022. Inclusion criteria were assessment of preterm infants, nutritional intake before 1 month corrected age, and WM outcome. Methods were congruent with the PRISMA-ScR checklist. Thirty-two articles were included. Negative associations were found between longer parenteral feeding duration and WM development, although likely confounded by illness. Positive associations between macronutrient, energy, and human milk intake and WM development were common, especially when fed enterally. Results on fatty acid and glutamine supplementation remained inconclusive. Significant associations were most often detected at the microstructural level using diffusion magnetic resonance imaging. Optimizing postnatal nutrition can positively influence WM development and subsequent NDO in preterm infants, but more controlled intervention studies using quantitative neuroimaging are needed. IMPACT: White matter brain injury is common in preterm infants and associated with impaired neurodevelopmental outcome. Optimizing postnatal nutrition can positively influence white matter development and subsequent neurodevelopmental outcome in preterm infants. More studies are needed, using quantitative neuroimaging techniques and interventional designs controlling for confounders, to define optimal nutritional intakes in preterm infants.

Indexed as

Infant Nutritional Physiological PhenomenaInfant, PrematureNutritional StatusWhite MatterEnteral NutritionHumansInfantInfant, NewbornNeurodevelopmentParenteral Nutrition

Identifiers

PMID37147439
OpenAlexW4372298418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.