Evidence map›Paper›PMID 37147413›Full record

ArticleScientific reports2023

Denoising diffusion probabilistic models for 3D medical image generation.

Firas Khader, Gustav Müller-Franzes, Soroosh Tayebi Arasteh, Tianyu Han, Christoph Haarburger, Maximilian Schulze-Hagen, Philipp Schad, Sandy Engelhardt, Bettina Baeßler, Sebastian Foersch and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed.

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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Firas KhaderDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.
Gustav Müller-FranzesDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.
Soroosh Tayebi ArastehDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.
Tianyu HanPhysics of Molecular Imaging Systems, Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
Christoph HaarburgerOcumeda GmbH, Munich, Germany.
Maximilian Schulze-HagenDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.
Philipp SchadDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.
Sandy EngelhardtArtificial Intelligence in Cardiovascular Medicine, University Hospital, Heidelberg, Germany.
Bettina BaeßlerDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany.
Sebastian FoerschMedical Clinic I, University of Mainz, Mainz, Germany.
Johannes StegmaierInstitute of Imaging and Computer Vision, RWTH Aachen, Aachen, Germany.
Christiane KuhlDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.
Sven NebelungDepartment of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.
Jakob Nikolas Kather *Department of Medicine III, University Hospital Aachen, Aachen, Germany.
Daniel Truhn *Department of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany. dtruhn@ukaachen.de.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Department of Health NIHR213331NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Recent advances in computer vision have shown promising results in image generation. Diffusion probabilistic models have generated realistic images from textual input, as demonstrated by DALL-E 2, Imagen, and Stable Diffusion. However, their use in medicine, where imaging data typically comprises three-dimensional volumes, has not been systematically evaluated. Synthetic images may play a crucial role in privacy-preserving artificial intelligence and can also be used to augment small datasets. We show that diffusion probabilistic models can synthesize high-quality medical data for magnetic resonance imaging (MRI) and computed tomography (CT). For quantitative evaluation, two radiologists rated the quality of the synthesized images regarding "realistic image appearance", "anatomical correctness", and "consistency between slices". Furthermore, we demonstrate that synthetic images can be used in self-supervised pre-training and improve the performance of breast segmentation models when data is scarce (Dice scores, 0.91 [without synthetic data], 0.95 [with synthetic data]).

Indexed as

Artificial IntelligenceImaging, Three-DimensionalImage Processing, Computer-AssistedMagnetic Resonance ImagingModels, StatisticalTomography, X-Ray Computed

Identifiers

PMID37147413
PMCPMC10163245

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.