Evidence map›Paper›PMID 37147374›Full record

ArticleScientific reports2023

Genetic dissection of behavioral traits related to successful training of drug detection dogs.

Yuki Matsumoto, Akitsugu Konno, Genki Ishihara, Miho Inoue-Murayama

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yuki MatsumotoAnicom Specialty Medical Institute Inc., Yokohama, Kanagawa, 231-0033, Japan.
Akitsugu KonnoDepartment of Animal Sciences, Teikyo University of Science, Uenohara, Yamanashi, 409-0193, Japan.
Genki IshiharaAnicom Specialty Medical Institute Inc., Yokohama, Kanagawa, 231-0033, Japan.
Miho Inoue-MurayamaWildlife Research Center, Kyoto University, Kyoto, Kyoto, 606-8203, Japan. murayama.miho.5n@kyoto-u.ac.jp.
Kyoto University · JPTeikyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug detection dogs play integral roles in society. However, the interplay between their behaviors and genetic characteristics underlying their performance remains uninvestigated. Herein, more than 120,000 genetic variants were evaluated in 326 German Shepherd or Labrador Retriever dogs to profile the genetic traits associated with various behavioral traits related to the successful training of drug detection dogs. Behavioral breed differences were observed in 'friendliness to humans' and 'tolerance to dogs.' A genome-wide association study within both breeds identified 11 regions potentially associated with drug detection dog characteristics as well as 'interest in the target' and 'friendliness to humans,' which are related to drug detection abilities. Among them, 63 protein-coding genes, including Atat1 and Pfn2 known to be associated with anxiety-related or exploration behavior in mice, respectively, were located surrounding the identified candidate polymorphisms. This study highlights genetic characteristics associated with behavioral traits that are important for the successful training of drug detection dogs. Thus, these findings may facilitate improved breeding and training of these dogs.

Indexed as

Genome-Wide Association StudyWorking DogsAnimalsDogsExploratory BehaviorHumansMicePhenotypePolymorphism, GeneticProfilinsPFN2 protein, humanProfilins

Identifiers

PMID37147374
PMCPMC10163243
OpenAlexW4372333040

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.