ArticleBMJ open2023
Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Neuropsychiatric outcomes after montelukast versus inhaled corticosteroids in pediatric asthma: a pooled birth cohort study.BMC medicine · 2026Article
- Body Composition and Muscle Function in Bronchiectasis: A Comparative Longitudinal Study.Respirology (Carlton, Vic.) · 2026Article
- Enhancing procedural quality and efficiency of methacholine bronchial challenge tests in patients with suspected cough-variant asthma: a quasi-experimental study utilizing nurse-patient communication and respiratory training.Frontiers in medicine · 2026Article
- Melatonin alleviates airway inflammation and anxiety-depression in asthma via gut microbiota-SCFA axis-mediated inhibition of microglial activation.Frontiers in immunology · 2026Article
- Age-Related Variations and Seasonal Influences: A Network Analysis of Comorbidities in Asthma Hospitalizations (2013-2023).Journal of clinical medicine · 2025Article
- The impact of asthma education grounded in virtual reality technology upon the quality of life of pediatric patients with bronchial asthma.Frontiers in pediatrics · 2025Article
- Article
- Asthma medication adherence, control, and psychological symptoms: a cross-sectional study.BMC pulmonary medicine · 2024Article
- The Association of Asthma with Anxiety, Depression, and Mild Cognitive Impairment among Middle-Aged and Elderly Individuals in Saudi Arabia.Behavioral sciences (Basel, Switzerland) · 2023Article
- Severe Asthma Management in Spain: A Survey-Based National Study. Is it Time for a National Asthma Plan?Open respiratory archivesArticle
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Authors and funding
46 authors at 18 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesAnxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Five Dimension Questionnaire (EQ-5D); the level of agreement between these questionnaires, and the factors associated with these symptoms.
methodsThis is a secondary analysis of the INSPIRERS studies. A total of 614 adolescents and adults with persistent asthma (32.6±16.9 years, 64.7% female) were recruited from 30 primary care centres and 32 allergy, pulmonology and paediatric clinics. Demographic and clinical characteristics, HADS and EQ-5D were collected. A score ≥8 on Hospital Anxiety and Depression Scale-Anxiety/Hospital Anxiety and Depression Scale-Depression or a positive answer to EQ-5D item 5 indicated the presence of these symptoms. Agreement was determined by Cohen's kappa. Two multivariable logistic regressions were built.
resultsAccording to HADS, 36% of the participants had symptoms of anxiety and 12% of depression. According to EQ-5D, 36% of the participants had anxiety/depression. The agreement between questionnaires in identifying anxiety/depression was moderate (k=0.55, 95% CI 0.48 to 0.62). Late asthma diagnosis, comorbidities and female gender were predictors of anxiety/depression, while better asthma control, health-related quality of life and perception of health were associated with lower odds for anxiety/depression.
conclusionAt least 1/3 of the patients with persistent asthma experience symptoms of anxiety/depression, showing the relevance of screening these disorders in patients with asthma. EQ-5D and HADS questionnaires showed a moderate agreement in the identification of anxiety/depression symptoms. The identified associated factors need to be further investigated in long-term studies.
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