Evidence map›Paper›PMID 37146571›Full record

ArticleStructure (London, England : 1993)2023

Tails don't tell the whole story.

Mikel Garcia-Marcos

Abstract readComment
PubMed Publisher
In one paragraph

Article in Structure (London, England : 1993), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Mikel Garcia-MarcosDepartment of Biochemistry & Cell Biology, Chobanian& Avedisian School of Medicine, Boston University, Boston, MA 02115, USA; Department of Biology, College of Arts & Sciences, Boston University, Boston, MA 02115, USA. Electronic address: mgm1@bu.edu.

Funding

Alternative Mechanisms of Signaling Via Trimeric G ProteinsR01NS117101 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Mikel Garcia-Marcos · 2020 to 2026
$3.4M
Non-canonical activation of heterotrimeric G protein signaling in vivoR01GM136132 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GARCIA-MARCOS, MIKEL · 2019 to 2022
$1.9M
Versatile and high-fidelity optical biosensor platforms for GPCR signalingR01GM147931 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GARCIA-MARCOS, MIKEL · 2023 to 2024
$850k
NIGMS NIH HHS R01 GM136132NIGMS NIH HHS R01 GM147931NINDS NIH HHS R01 NS117101
6 · The paper itself

Abstract

Before engaging G protein-coupled receptors (GPCRs) to transduce extracellular signals, heterotrimeric G proteins (Gαβγ) must fold properly with the help of chaperones. In this issue of Structure, Papasergi-Scott et al. (2023) unveil the molecular basis for how mammalian Ric-8 chaperones achieve selectivity for their respective Gα subunit clients.

Indexed as

Guanine Nucleotide Exchange FactorsReceptors, G-Protein-CoupledAnimalsHumansMammalsMolecular ChaperonesGuanine Nucleotide Exchange FactorsMolecular ChaperonesReceptors, G-Protein-Coupled

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.