ArticlePsychiatry research2023
Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.
Article in Psychiatry research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Genetic interconnections between personality-related phenotypes and psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Joint association of frailty and social isolation with depressive symptoms among middle-aged and older Chinese adults: a nationwide cohort study.Scientific reports · 2026Article
- Loneliness in adolescents and youth with bipolar disorder: a scoping review.Frontiers in psychiatry · 2026Review
- Substance use and generalized anxiety disorder in university students: evidence from the university of Douala, Cameroon.BMC psychiatry · 2025Article
- Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses.BMC medicine · 2025Article
- Prospective Associations Among Loneliness and Health for Servicemembers: Perceived Helplessness and Negative Coping Appraisal as Explanatory Mechanisms.Behavioral sciences (Basel, Switzerland) · 2025Article
- The BioSUD Biobank as a genomic resource for substance use disorders in Italy.Scientific reports · 2025Article
- Loneliness in South African youth and its association with HIV infection, substance use and mental health.International journal of adolescence and youth · 2025Article
- Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample.medRxiv : the preprint server for health sciences · 2024Article
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Authors and funding
4 authors.
Funding
Abstract
Loneliness is a common, yet distressing experience associated with adverse outcomes including substance use problems and psychiatric disorders. To what extent these associations reflect genetic correlations and causal relationships is currently unclear. We applied Genomic Structural Equation Modelling (GSEM) to dissect the genetic architecture between loneliness and psychiatric-behavioural traits. Included were summary statistics from 12 genome-wide association analyses, including loneliness and 11 psychiatric phenotypes (range N: 9,537 - 807,553). We first modelled latent genetic factors amongst the psychiatric traits to then investigate potential causal effects between loneliness and the identified latent factors, using multivariate genome-wide association analyses and bidirectional Mendelian randomization. We identified three latent genetic factors, encompassing neurodevelopmental/mood conditions, substance use traits and disorders with psychotic features. GSEM provided evidence of a unique association between loneliness and the neurodevelopmental/mood conditions latent factor. Mendelian randomization results were suggestive of bidirectional causal effects between loneliness and the neurodevelopmental/mood conditions factor. These results imply that a genetic predisposition to loneliness may elevate the risk of neurodevelopmental/mood conditions, and vice versa. However, results may reflect the difficulty of distiguishing between loneliness and neurodevelopmental/mood conditions, which present in similar ways. We suggest, overall, the importance of addressing loneliness in mental health prevention and policy.
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