Evidence map›Paper›PMID 37146302›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Rhabdomyosarcomas are oncogene addicted to the activation of AVIL.

Zhongqiu Xie, Pawel L Janczyk, Xinrui Shi, Qiong Wang, Sandeep Singh, Robert Cornelison, Jingjing Xu, James W Mandell, Frederic G Barr, Hui Li

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The role of TET2 in solid tumors and its therapeutic potential: a comprehensive review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Zhongqiu XieDepartment of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-2869-7669
Pawel L JanczykDepartment of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Xinrui ShiDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Qiong WangDepartment of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0003-2564-7778
Sandeep SinghDepartment of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0001-5361-4303
Robert CornelisonDepartment of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Jingjing XuDepartment of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908.
James W MandellDepartment of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-5000-8276
Frederic G BarrLaboratory of Pathology, National Cancer Institute, Bethesda, MD 20892.ORCID 0000-0002-1051-7447
Hui LiDepartment of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-7879-1792
University of Virginia · USNational Cancer Institute · USSun Yat-sen University · CNTongji Hospital · CN

Funding

Targeting AVIL in GlioblastomaR01CA240601 · NCI · UNIVERSITY OF VIRGINIA · PI LI, HUI · 2020 to 2024
$2.4M
Targeting AVIL, a novel oncogene in rhabdomyosarcomaR01CA269594 · NCI · UNIVERSITY OF VIRGINIA · PI HUI LI · 2023 to 2026
$2.0M
NCI NIH HHS R01 CA240601NCI NIH HHS R01 CA269594
6 · The paper itself

Abstract

Rhabdomyosarcoma (RMS) is one of the most common pediatric soft-tissue cancer. Previously, we discovered a gene fusion,

Indexed as

RhabdomyosarcomaRhabdomyosarcoma, AlveolarAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceMicrofilament ProteinsOncogene Proteins, FusionOncogenesPaired Box Transcription FactorsPheniramineAVIL protein, humanMicrofilament ProteinsOncogene Proteins, FusionPaired Box Transcription FactorsPheniramineAVILMARS-AVILoncogenerhabdomyosarcoma

Identifiers

PMID37146302
PMCPMC9214494
OpenAlexW4286285449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.