SynthesisReproductive sciences (Thousand Oaks, Calif.)2023
Assisted Reproductive Techniques and Risk of Congenital Heart Diseases in Children: a Systematic Review and Meta-analysis.
Synthesis in Reproductive sciences (Thousand Oaks, Calif.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Fertility treatment and risk of non-gynecological cancer: a systematic review.Archives of gynecology and obstetrics · 2026Pooled it
- Attitude towards assisted reproductive technology: acceptance of donors eggs, sperms, and embryos as treatment of human infertility: a systematic review and meta-analysis.Reproductive health · 2024Pooled it
- The impact of previous history of malignant tumors/precancerous lesions on IVF/ICSI outcomes: a retrospective cohort study.Annals of medicine · 2026Article
- Effects of assisted reproductive techniques on offspring cardiovascular health: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2026Review
- Observed Prevalence and Predictors of Congenital Heart Disease in Infants Conceived via In vitro Fertilization.Pediatric cardiology · 2026Article
- Risk of minor congenital heart defect in infants conceived via assisted reproductive technology: cohort study from the Copenhagen Baby Heart Study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- The Impact of Maternal Obesity and Diabetes on the Development of Congenital Heart Defects (CHDs) in Offspring: A Narrative Review.Metabolites · 2026Review
- Uterine fibroids detected in early pregnancy and their association with adverse pregnancy outcomes: a single-centre retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Ovarian torsion of a large mature cystic teratoma complicating early pregnancy: a rare case report.International journal of surgery case reports · 2026Article
- Prevalence of Congenital Aortic Valve Regurgitation in a Newborn Cohort.Pediatric cardiology · 2026Article
- Robotic assisted versus conventional laparoscopic ovarian suture reapproximation in ovarian cystectomy of ovarian endometriomas in preserving ovarian reserve.Journal of robotic surgery · 2026Article
- Machine learning-based preliminary screening tool for clinical pregnancy prediction: towards management of IVF/ICSI stages.Annals of medicine · 2025Article
- Construction of a novel ferroptosis-related long non-coding RNAs model for predicting prognosis and tumor immune microenvironment in endometrial cancer.Annals of translational medicine · 2025Article
- Global, regional, and national burden and trends of endometriosis, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2050.BMC women's health · 2025Article
- IVF and pregnancy outcomes: the triumphs, challenges, and unanswered questions.Journal of ovarian research · 2025Review
- Differences in the EarlyJournal of cardiovascular development and disease · 2025Article
- Review
- DiGeorge Syndrome in newborns conceived from assisted reproductive techniques: is preimplantation screening necessary? A discussion of two cases.Journal of assisted reproduction and genetics · 2025Article
- Maternal and Fetal-Neonatal Complications of Romanian Women with Gestational Diabetes: A Retrospective Comparative Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Fraser Syndrome: A Narrative Review Based on a Case from Vietnam and the Past 20 Years of Research.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility is a growing phenomenon and leads to an increased use of assisted reproductive techniques (ARTs). In recent years, concerns about the safety of these procedures emerged and ARTs were hypothesized to be a risk factor for developing congenital heart diseases (CHDs) in offspring. Our aim is to investigate the association between ART and CHD, specifying results according to various subtypes of defects. We performed a systematic review and random-effects meta-analysis following the PRISMA guidelines. MEDLINE and Google Scholar were searched from January 2011 to May 2022. Data about incidence of CHD in ART were tabulated and extracted from all the studies included. Twenty-four studies were included. Pooled incidence of CHDs after IVF pregnancies was 3% (95% CI 0.3-0.4; I
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.