Evidence map›Paper›PMID 37145284›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2023

Genetic Mouse Models of Pneumocystis Pneumonia.

J Claire Hoving, Ferris T Munyonho, Jay K Kolls

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The pathogenesis of experimental Emergomycosis in mice.PLoS neglected tropical diseases · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J Claire HovingAFRICA CMM Medical Mycology Research Unit, Institute of Infectious Disease and Molecular Medicine (IDM), Cape Town, South Africa. Jennifer.hoving@uct.ac.za.
Ferris T MunyonhoCentre for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, LA, USA.
Jay K KollsCentre for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, LA, USA. jkolls1@tulane.edu.

Funding

Wellcome Trust 209293/Z/17/Z
6 · The paper itself

Abstract

Pneumocystis jirovecii causes pneumonia in immunocompromised patients. A major challenge in drug susceptibility testing and in understanding host/pathogen interactions is that Pneumocystis spp. are not viable in vitro. Continuous culture of the organism is not currently available, and therefore, developing new drug targets is very limited. Due to this limitation, mouse models of Pneumocystis pneumonia have proven to be an invaluable resource to researchers. In this chapter, we provide an overview of selected methods used in mouse models of infection including, in vivo Pneumocystis murina propagation, routes of transmission, genetic mouse models available, a P. murina life form-specific model, a mouse model of PCP immune reconstitution inflammatory syndrome (IRIS), and the experimental parameters associated with these models.

Indexed as

Mycobacterium tuberculosisPneumocystis cariniiPneumonia, PneumocystisAnimalsMiceMicrobial Sensitivity TestsImmune responseImmunocompromisedLung fungal infectionPneumocystis murinaRag1-deficient

Identifiers

PMID37145284

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.