Evidence map›Paper›PMID 37145214›Full record

ArticleLa Radiologia medica2023

Whole body MRI with Diffusion Weighted Imaging versus 18F-fluorodeoxyglucose-PET/CT in the staging of lymphomas.

Francesca Maccioni, Giulia Alfieri, Giovanni Manfredi Assanto, Monica Mattone, Guido Gentiloni Silveri, Federica Viola, Alessandro De Maio, Viviana Frantellizzi, Alice Di Rocco, Giuseppe De Vincentis and 3 more

Abstract read
In one paragraph

Article in La Radiologia medica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Francesca MaccioniDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale Regina Elena 324, 00161, Rome, Italy. Francesca.maccioni@uniroma1.it.ORCID http://orcid.org/0000-0001-7599-0289
Giulia AlfieriDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale Regina Elena 324, 00161, Rome, Italy.
Giovanni Manfredi AssantoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Policlinico Umberto I Hospital, Via Benevento 6, 00161, Rome, Italy.
Monica MattoneDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale Regina Elena 324, 00161, Rome, Italy.
Guido Gentiloni SilveriDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale Regina Elena 324, 00161, Rome, Italy.
Federica ViolaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Policlinico Umberto I Hospital, Via Benevento 6, 00161, Rome, Italy.
Alessandro De MaioDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale Regina Elena 324, 00161, Rome, Italy.
Viviana FrantellizziDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale Regina Elena 324, 00161, Rome, Italy.
Alice Di RoccoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Policlinico Umberto I Hospital, Via Benevento 6, 00161, Rome, Italy.
Giuseppe De VincentisDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale Regina Elena 324, 00161, Rome, Italy.
Alessandro PulsoniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Policlinico Umberto I Hospital, Via Benevento 6, 00161, Rome, Italy.
Maurizio MartelliDepartment of Translational and Precision Medicine, Sapienza University of Rome, Policlinico Umberto I Hospital, Via Benevento 6, 00161, Rome, Italy.
Carlo CatalanoDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale Regina Elena 324, 00161, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the diagnostic performance of Whole Body (WB)-MRI in comparison with 18F-Fluorodeoxyglucose-PET/CT (18F-FDG-PET/CT) in lymphoma staging and to assess whether quantitative metabolic parameters from 18F-FDG-PET/CT and Apparent Diffusion Coefficient (ADC) values are related. MATERIALS AND

methodsWe prospectively enrolled patients with a histologically proven primary nodal lymphoma to  undergo 18F-FDG-PET/CT and WB-MRI, both performed within 15 days one from the other, either before starting treatment (baseline) or during treatment (interim). Positive and negative predictive values of WB-MRI for the identification of nodal and extra-nodal disease were measured. The agreement between WB-MRI and 18F-FDG-PET/CT for the identification of lesions and staging was assessed through Cohen's coefficient k and observed agreement. Quantitative parameters of nodal lesions derived from 18F-FDG-PET/CT and WB-MRI (ADC) were measured and the Pearson or Spearman correlation coefficient was used to assess the correlation between them. The specified level of significance was p ≤ 0.05.

resultsAmong the 91 identified patients, 8 refused to participate and 22 met exclusion criteria, thus images from 61 patients (37 men, mean age 30.7 years) were evaluated. The agreement between 18F-FDG-PET/CT and WB-MRI for the identification of nodal and extra-nodal lesions was 0.95 (95% CI 0.92 to 0.98) and 1.00 (95% CI NA), respectively; for staging it was 1.00 (95% CI NA). A strong negative correlation was found between ADCmean and SUVmean of nodal lesions in patients evaluated at baseline (Spearman coefficient r

conclusionWB-MRI has a good diagnostic performance for staging of patients with lymphoma in comparison with 18F-FDG-PET/CT and is a promising technique for the quantitative assessment of disease burden in these patients.

Indexed as

Fluorodeoxyglucose F18LymphomaAdultDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingMaleNeoplasm StagingPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsWhole Body ImagingFluorodeoxyglucose F18Radiopharmaceuticals18F-fluorodeoxyglucose-PET/CTChemotherapyDiffusion Weighted ImagingLymphomaWhole-body-Magnetic Resonance Imaging

Identifiers

PMID37145214
PMCPMC10182138

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