Evidence map›Paper›PMID 37145019›Full record

ReviewCancer medicine2023

Management of pheochromocytomas and paragangliomas: Review of current diagnosis and treatment options.

Michal Eid, Jakub Foukal, Dana Sochorová, Štěpán Tuček, Karel Starý, Zdeněk Kala, Jiří Mayer, Radim Němeček, Jan Trna, Lumír Kunovský

Open access · goldAbstract readReview
In one paragraph

Review in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Treatment with radiotherapy in carotidal paraganglioma: experience of the General Hospital of Mexico.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  6. Late Onset Malignant Metastatic Transformation of Benign Pheochromocytoma.Journal of community hospital internal medicine perspectives · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Michal EidDepartment of Hematology, Oncology and Internal Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-4433-5326
Jakub FoukalDepartment of Radiology and Nuclear Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0003-4321-401X
Dana SochorováDepartment of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0003-1925-2892
Štěpán TučekDepartment of Hematology, Oncology and Internal Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-4536-1155
Karel StarýDepartment of Gastroenterology and Internal Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Zdeněk KalaDepartment of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0003-4187-388X
Jiří MayerDepartment of Hematology, Oncology and Internal Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0003-0567-9887
Radim NěmečekDepartment of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0001-6825-0960
Jan TrnaDepartment of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0003-3138-9736
Lumír KunovskýDepartment of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0003-2985-8759
Masaryk University · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pheochromocytomas (PCCs) are rare neuroendocrine tumors derived from the chromaffin cells of the adrenal medulla. When these tumors have an extra-adrenal location, they are called paragangliomas (PGLs) and arise from sympathetic and parasympathetic ganglia, particularly of the para-aortic location. Up to 25% of PCCs/PGLs are associated with inherited genetic disorders. The majority of PCCs/PGLs exhibit indolent behavior. However, according to their affiliation to molecular clusters based on underlying genetic aberrations, their tumorigenesis, location, clinical symptomatology, and potential to metastasize are heterogenous. Thus, PCCs/PGLs are often associated with diagnostic difficulties. In recent years, extensive research revealed a broad genetic background and multiple signaling pathways leading to tumor development. Along with this, the diagnostic and therapeutic options were also expanded. In this review, we focus on the current knowledge and recent advancements in the diagnosis and treatment of PCCs/PGLs with respect to the underlying gene alterations while also discussing future perspectives in this field.

Indexed as

Adrenal Gland NeoplasmsParagangliomaPheochromocytomaCarcinogenesisCell Transformation, NeoplasticHumansbiomarkerschemotherapymolecular biologyprognostic factorsurgerytarget therapy

Identifiers

PMID37145019
PMCPMC10358258
OpenAlexW4372330882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.