Evidence map›Paper›PMID 37144963›Full record

ArticlePsychological medicine2023

Childhood trauma, antipsychotic medication, and symptom remission in first-episode psychosis.

Akiah Ottesen, W T V Hegelstad, Inge Joa, Stein E Opjordsmoen, Bjørn Rishovd Rund, Jan Ivar Røssberg, Erik Simonsen, Jan Olav Johannessen, Tor K Larsen, Ulrik Helt Haahr and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Akiah OttesenNORMENT Centre, Division of Mental Health and Addiction Oslo University Hospital, Oslo, Norway.ORCID 0000-0003-0025-5612
W T V HegelstadTIPS Centre for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norway.
Inge JoaTIPS Centre for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norway.
Stein E OpjordsmoenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Bjørn Rishovd RundDepartment of Psychology, University of Oslo, Oslo, Norway.
Jan Ivar RøssbergInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Erik SimonsenPsychiatric Research Unit, Psychiatry Region Zealand, Slagelse, Denmark.
Jan Olav JohannessenTIPS Centre for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norway.
Tor K LarsenTIPS Centre for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norway.
Ulrik Helt HaahrPsychiatric Research Unit, Psychiatry Region Zealand, Slagelse, Denmark.
Thomas H McGlashanDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Svein FriisInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ingrid MelleNORMENT Centre, Division of Mental Health and Addiction Oslo University Hospital, Oslo, Norway.
Oslo University Hospital · NOStavanger University Hospital · NORegion Zealand · DKUniversity of Copenhagen · DKUniversity of Oslo · NOYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo what extent psychotic symptoms in first-episode psychosis (FEP) with a history of childhood interpersonal trauma (CIT) are less responsive to antipsychotic medication is not known. In this longitudinal study, we compare symptom trajectories and remission over the first 2 years of treatment in FEP with and without CIT and examine if differences are linked to the use of antipsychotics.

methodsFEP (

resultsCIT (

conclusionResults indicate that antipsychotic medication is equally beneficial in the achievement of symptomatic remission in FEP after 2 years independent of CIT. Still, FEP patients with CIT had more severe positive, depressive, and excited symptoms throughout.

Indexed as

Adverse Childhood ExperiencesAntipsychotic AgentsPsychotic DisordersHumansLongitudinal StudiesAntipsychotic AgentsAnti-psychotic medicationchildhood interpersonal traumafirst-episode psychosisoutcomesymptomatic remission

Identifiers

PMID37144963
PMCPMC10123824
OpenAlexW3213515068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.