ArticleeLife2023
The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Reply to Tarchini et al.: Evidence for a GPR156 role in central stress responses in addition to its inner-ear function.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling.Development (Cambridge, England) · 2026Article
- GPR156 is required in sensory hair cells for proper auditory and vestibular function.Scientific reports · 2026Article
- Planar polarized organization of mouse hair cells is established and maintained by STK32A, GPR156 and EMX2.Journal of cell science · 2025Article
- Stem and progenitor cell proliferation are independently regulated by cell type-specific cyclinD genes.Nature communications · 2025Article
- Emx2 lineage tracing reveals antecedent patterns of planar polarity in the mouse inner ear.Development (Cambridge, England) · 2024Article
- Article
- Effects of aging on otolith morphology and functions in mice.Frontiers in neuroscience · 2024Article
- TMC function, dysfunction, and restoration in mouse vestibular organs.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The vestibular maculae of the inner ear contain sensory receptor hair cells that detect linear acceleration and contribute to equilibrioception to coordinate posture and ambulatory movements. These hair cells are divided between two groups, separated by a line of polarity reversal (LPR), with oppositely oriented planar-polarized stereociliary bundles that detect motion in opposite directions. The transcription factor EMX2 is known to establish this planar polarized organization in mouse by regulating the distribution of the transmembrane receptor GPR156 at hair cell boundaries in one group of cells. However, the genes regulated by EMX2 in this context were previously not known. Using mouse as a model, we have identified the serine threonine kinase STK32A as a downstream effector negatively regulated by EMX2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.