Evidence map›Paper›PMID 37144470›Full record

Trial reportChronobiology international2023

Sound and light levels in intensive care units in a large urban hospital in the United States.

Michael J Leone, Hassan S Dashti, Brian Coughlin, Ryan A Tesh, Syed A Quadri, Abigail A Bucklin, Noor Adra, Parimala Velpula Krishnamurthy, Elissa M Ye, Aashritha Hemmige and 14 more

Erratum issued Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Chronobiology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03355053 (Investigation of Sleep in the Intensive Care Unit), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355053 phase2completednot on this map

Investigation of Sleep in the Intensive Care Unit

TypeinterventionalSponsorMassachusetts General HospitalRan2018 to 2023Enrolled522ConditionsDelirium, SleepArmsDexmedetomidine, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Sleep physiology and critical illness: A narrative review.Journal of the Intensive Care Society · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Michael J LeoneDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Hassan S DashtiCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Brian CoughlinDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ryan A TeshDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Syed A QuadriDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Abigail A BucklinDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Noor AdraDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Parimala Velpula KrishnamurthyDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Elissa M YeDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Aashritha HemmigeDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Subapriya RajanDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ezhil PanneerselvamDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jasmine HigginsDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Muhammad Abubakar AyubDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Wolfgang GanglbergerDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Luis PaixaoDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Timothy T HouleSleep & Health Zurich, University of Zurich, Zurich, Switzerland.
B Taylor ThompsonDivision of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
Oluwaseun Johnson-AkejuDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Eyal KimchiDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Sydney S CashDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Robert J ThomasClinical Data Animation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
M Brandon WestoverDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Funding

Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and MortalityR01HL161253 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CLIFFORD, GARI DAVID, MIGNOT, EMMANUEL J · 2022 to 2025
$8.3M
Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)R01NS102190 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$3.2M
Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain InjuryR01NS126282 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Aaron F Struck, Michael Brandon Westover · 2023 to 2026
$2.9M
Big Data and Deep Learning for the Interictal-Ictal-Injury ContiuumR01NS107291 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$2.8M
Establishing a Brain Health Index from the Sleep ElectroencephalogramRF1NS120947 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2021 to 2021
$2.4M
The impact of overnight nutrition support on sleep and circadian rhythm disruption in the ICUK99HL153795 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DASHTI, HASSAN S. · 2021 to 2022
$330k
NHLBI NIH HHS K99 HL153795NHLBI NIH HHS R01 HL161253NINDS NIH HHS R01 NS102190NINDS NIH HHS R01 NS107291NINDS NIH HHS R01 NS126282NINDS NIH HHS RF1 NS120947
6 · The paper itself

Abstract

Intensive care units (ICUs) may disrupt sleep. Quantitative ICU studies of concurrent and continuous sound and light levels and timings remain sparse in part due to the lack of ICU equipment that monitors sound and light. Here, we describe sound and light levels across three adult ICUs in a large urban United States tertiary care hospital using a novel sensor. The novel sound and light sensor is composed of a Gravity Sound Level Meter for sound level measurements and an Adafruit TSL2561 digital luminosity sensor for light levels. Sound and light levels were continuously monitored in the room of 136 patients (mean age = 67.0 (8.7) years, 44.9% female) enrolled in the Investigation of Sleep in the Intensive Care Unit study (ICU-SLEEP; Clinicaltrials.gov: #NCT03355053), at the Massachusetts General Hospital. The hours of available sound and light data ranged from 24.0 to 72.2 hours. Average sound and light levels oscillated throughout the day and night. On average, the loudest hour was 17:00 and the quietest hour was 02:00. Average light levels were brightest at 09:00 and dimmest at 04:00. For all participants, average nightly sound levels exceeded the WHO guideline of < 35 decibels. Similarly, mean nightly light levels varied across participants (minimum: 1.00 lux, maximum: 577.05 lux). Sound and light events were more frequent between 08:00 and 20:00 than between 20:00 and 08:00 and were largely similar on weekdays and weekend days. Peaks in distinct alarm frequencies (Alarm 1) occurred at 01:00, 06:00, and at 20:00. Alarms at other frequencies (Alarm 2) were relatively consistent throughout the day and night, with a small peak at 20:00. In conclusion, we present a sound and light data collection method and results from a cohort of critically ill patients, demonstrating excess sound and light levels across multiple ICUs in a large tertiary care hospital in the United States. ClinicalTrials.gov, #NCT03355053. Registered 28 November 2017, https://clinicaltrials.gov/ct2/show/NCT03355053.

Indexed as

Circadian RhythmIntensive Care UnitsAdultAgedFemaleHospitals, UrbanHumansMaleMiddle AgedNoiseSleepUnited Statescritical illnessdevicesIntensive care unitslightsoundurban hospitals

Identifiers

PMID37144470
PMCPMC10524721

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.