Evidence map›Paper›PMID 37144459›Full record

ArticleNucleic acids research2023

g:Profiler-interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update).

Liis Kolberg, Uku Raudvere, Ivan Kuzmin, Priit Adler, Jaak Vilo, Hedi Peterson

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,122 papers.

0numbers the graph read from it
0cells of the map it votes in
1,122citing papers in PubMed
225.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,122 citing papers in PubMed, 1,440 citations in OpenAlex.

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1,062 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Liis KolbergInstitute of Computer Science, University of Tartu, Narva mnt 18, 51009 Tartu, Estonia.ORCID 0000-0002-0118-7562
Uku RaudvereInstitute of Computer Science, University of Tartu, Narva mnt 18, 51009 Tartu, Estonia.ORCID 0000-0001-7243-8595
Ivan KuzminInstitute of Computer Science, University of Tartu, Narva mnt 18, 51009 Tartu, Estonia.ORCID 0000-0001-9138-9901
Priit AdlerInstitute of Computer Science, University of Tartu, Narva mnt 18, 51009 Tartu, Estonia.ORCID 0000-0001-8276-5135
Jaak ViloInstitute of Computer Science, University of Tartu, Narva mnt 18, 51009 Tartu, Estonia.ORCID 0000-0001-5604-4107
Hedi PetersonInstitute of Computer Science, University of Tartu, Narva mnt 18, 51009 Tartu, Estonia.ORCID 0000-0001-9951-5116
University of Tartu · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

g:Profiler is a reliable and up-to-date functional enrichment analysis tool that supports various evidence types, identifier types and organisms. The toolset integrates many databases, including Gene Ontology, KEGG and TRANSFAC, to provide a comprehensive and in-depth analysis of gene lists. It also provides interactive and intuitive user interfaces and supports ordered queries and custom statistical backgrounds, among other settings. g:Profiler provides multiple programmatic interfaces to access its functionality. These can be easily integrated into custom workflows and external tools, making them valuable resources for researchers who want to develop their own solutions. g:Profiler has been available since 2007 and is used to analyse millions of queries. Research reproducibility and transparency are achieved by maintaining working versions of all past database releases since 2015. g:Profiler supports 849 species, including vertebrates, plants, fungi, insects and parasites, and can analyse any organism through user-uploaded custom annotation files. In this update article, we introduce a novel filtering method highlighting Gene Ontology driver terms, accompanied by new graph visualizations providing a broader context for significant Gene Ontology terms. As a leading enrichment analysis and gene list interoperability service, g:Profiler offers a valuable resource for genetics, biology and medical researchers. It is freely accessible at https://biit.cs.ut.ee/gprofiler.

Indexed as

Chromosome MappingComputational BiologyGenesSoftwareAnimalsDatabases, GeneticHumansInternetReproducibility of ResultsUser-Computer Interface

Identifiers

PMID37144459
PMCPMC10320099
OpenAlexW4372332501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.