ReviewClinical science (London, England : 1979)2023
The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction.
Review in Clinical science (London, England : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 11 citations in OpenAlex.
- Dissipation of the mitochondrial proton motive force drives sepsis pathogenesis and explains hyperlactatemia's predictive value in sepsis mortality.World journal of critical care medicine · 2026Review
- Beyond the Pump: Unravelling Immunometabolic Crosstalk and Organelle Dynamics in Sepsis-Induced Cardiomyopathy.Journal of cardiovascular translational research · 2026Article
- Pathophysiology of distributive shock in sepsis: beyond vasoplegia.Intensive care medicine · 2026Article
- Impact of noradrenaline, adrenergic receptors, and radical formation on cardiac mitochondria in resuscitated swine.Intensive care medicine experimental · 2026Article
- Association of triglyceride-glucose index fluctuation with in-hospital all-cause mortality in critically ill patients: a multidatabase retrospective study.Scientific reports · 2026Observational
- Hormonal, biochemical and hematological changes in neonatal calves with sepsis induced by enteritis.Iranian journal of veterinary research · 2026Article
- Testosterone and androgen receptor pathway modulation in sepsis: immunometabolic mechanisms and therapeutic implications - a scoping review.Frontiers in endocrinology · 2026Article
- Immune-endothelial-coagulation crosstalk as a driver of multi-organ dysfunction in severe viral pneumonia.Frontiers in immunology · 2026Review
- Crosstalk between innate immune signaling pathways and integrated TLR, NLRP3 inflammasome, cGAS-STING, and NF-κB networks in sepsis.Frontiers in cell and developmental biology · 2026Review
- Thyroid hormone deficiency worsens outcomes in vaccinia virus infection.Journal of virology · 2025Article
- Protective role of triiodothyronine in sepsis‑induced cardiomyopathy through phospholamban downregulation.International journal of molecular medicine · 2025Article
- The therapeutic effect of norepinephrine alone or in combination with vasopressin on septic shock patients: a meta-analysis.American journal of translational research · 2025Review
- Infection Leading to Breast Abscess Formation in Pregnancy: A Case Report.International medical case reports journal · 2025Article
- Assessment of mitochondrial function and its prognostic role in sepsis: a literature review.Intensive care medicine experimental · 2024Review
- Effect of cortisol and glycosylated-hemoglobin levels on mortality in intensive care unit.Saudi medical journal · 2024Article
- The role of platelets in sepsis: A review.Biomolecules & biomedicine · 2024Review
- Relation of Plasma Catecholamine Concentrations and Myocardial Mitochondrial Respiratory Activity in Anesthetized and Mechanically Ventilated, Cardiovascular Healthy Swine.International journal of molecular sciences · 2023Article
- Association between sodium level trajectories and clinical prognosis in patients with sepsis: A longitudinal retrospective cohort study.Science progressArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents. Gene transcription and downstream pathways are either up- or downregulated, albeit with considerable fluctuation over the course of the patient's illness. This multi-system complexity contributes to a pathophysiology that remains to be fully elucidated. Consequentially, little progress has been made to date in developing new outcome-improving therapeutics. Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance. However, little attention has been paid to an integrated view of how these hormonal changes impact upon the development of organ dysfunction and recovery. Here, we present a narrative review describing the impact of the altered endocrine system on mitochondrial dysfunction and immune suppression, two interlinked and key aspects of sepsis pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.