Evidence map›Paper›PMID 37144161›Full record

ArticleFrontiers in human neuroscience2023

Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras.

Chiara Abagnale, Antonio Di Renzo, Gabriele Sebastianelli, Francesco Casillo, Emanuele Tinelli, Giada Giuliani, Maria Giulia Tullo, Mariano Serrao, Vincenzo Parisi, Marco Fiorelli and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Review
  6. Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Chiara AbagnaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Antonio Di RenzoIRCCS-Fondazione Bietti, Rome, Italy.
Gabriele SebastianelliDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Francesco CasilloDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Emanuele TinelliUnit of Neuroradiology, Department of Medical and Surgical Sciences, Magna Græcia University, Catanzaro, Italy.
Giada GiulianiDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Maria Giulia TulloDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Mariano SerraoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Vincenzo ParisiIRCCS-Fondazione Bietti, Rome, Italy.
Marco FiorelliDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Francesca CaramiaDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Jean SchoenenHeadache Research Unit, Department of Neurology, CHU de Liège, Citadelle Hospital, Liège, Belgium.
Vittorio Di PieroDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Gianluca CoppolaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Sapienza University of Rome · ITFondazione G.B. Bietti · ITCentre Hospitalier Universitaire de Liège · BEMagna Graecia University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The migrainous aura has different clinical phenotypes. While the various clinical differences are well-described, little is known about their neurophysiological underpinnings. To elucidate the latter, we compared white matter fiber bundles and gray matter cortical thickness between healthy controls (HC), patients with pure visual auras (MA) and patients with complex neurological auras (MA+). Methods: 3T MRI data were collected between attacks from 20 patients with MA and 15 with MA+, and compared with those from 19 HCs. We analyzed white matter fiber bundles using tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) and cortical thickness with surface-based morphometry of structural MRI data. Results: Tract-based spatial statistics showed no significant difference in diffusivity maps between the three subject groups. As compared to HCs, both MA and MA+ patients had significant cortical thinning in temporal, frontal, insular, postcentral, primary and associative visual areas. In the MA group, the right high-level visual-information-processing areas, including lingual gyrus, and the Rolandic operculum were thicker than in HCs, while in the MA+ group they were thinner. Discussion: These findings show that migraine with aura is associated with cortical thinning in multiple cortical areas and that the clinical heterogeneity of the aura is reflected by opposite thickness changes in high-level visual-information-processing, sensorimotor and language areas.

Indexed as

lingual gyrusmigraine auraRolandic operculumsurface-based morphometry (SBM)tract-based spatial statistics (TBSS)

Identifiers

PMID37144161
PMCPMC10151576
OpenAlexW4366291404

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.