Evidence map›Paper›PMID 37144041›Full record

ArticleClinical & translational immunology2023

CD137 deficiency because of two novel biallelic

Kefeng Shen, Jiachen Wang, Kuangguo Zhou, Wei Mu, Meilan Zhang, Xinyue Deng, Haodong Cai, Wei Zhang, Wei Huang, Min Xiao

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Agonist Antibodies for Cancer Immunotherapy: History, Hopes, and Challenges.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Kefeng ShenDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID https://orcid.org/0000-0003-4690-4040
Jiachen WangDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Kuangguo ZhouDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Wei MuDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Meilan ZhangDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Xinyue DengDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Haodong CaiDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Wei ZhangDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Wei HuangDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Min XiaoDepartment of Hematology, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID https://orcid.org/0000-0001-9421-6344
Tongji Hospital · CNHuman Factors (Norway) · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Increasing evidence indicates that some germline genetic mutations that impair pathways required for robust host immune surveillance against EBV infection may result in an extremely high susceptibility to EBV-associated lymphoproliferative disease (EBV Methods: Here, we report the first case of CD137 deficiency caused by two novel biallelic heterozygous Results: Biallelic Conclusion: Our study expands the genetic spectrum and clinical phenotype of patients with CD137 deficiency and provides additional evidence that the

Indexed as

EBV‐associated lymphoproliferative diseaseEBV infectiongermline genetic mutationprimary immunodeficiencyTNFRSF9

Identifiers

PMID37144041
PMCPMC10153300
OpenAlexW4368275010

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.