ReviewNeurophotonics2023
Intrinsic, widefield optical imaging of hemodynamics in rodent models of Alzheimer's disease and neurological injury.
Review in Neurophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Impact of the β correction factor on the accuracy of speckle contrast imaging measurements.Biomedical optics express · 2026Article
- A Mouse Cortex Video Segmentation Dataset for Intrinsic Optical Signal Tracking and Neural Activity Analysis.Scientific data · 2026Article
- Sensing Through Tissues Using Diffuse Optical Imaging and Genetic Programming.Sensors (Basel, Switzerland) · 2026Article
- Direct blood flow velocity measurements of zebrafish cerebral vessels with a dual-mode light-sheet microscope.Biomedical optics express · 2025Article
- 7 Tesla multimodal MRI dataset of ex-vivo human brain.Scientific data · 2025Article
- Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease.Neurophotonics · 2025Article
- A Brief Introduction to the Study of Cerebral Blood Flow Measurement in Traumatic Brain Injury Using Optical Imaging Approach.Korean journal of neurotrauma · 2024Article
- Quantitative hemodynamic imaging: a method to correct the effects of optical properties on laser speckle imaging.Neurophotonics · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The complex cerebrovascular network is critical to controlling local cerebral blood flow (CBF) and maintaining brain homeostasis. Alzheimer's disease (AD) and neurological injury can result in impaired CBF regulation, blood-brain barrier breakdown, neurovascular dysregulation, and ultimately impaired brain homeostasis. Measuring cortical hemodynamic changes in rodents can help elucidate the complex physiological dynamics that occur in AD and neurological injury. Widefield optical imaging approaches can measure hemodynamic information, such as CBF and oxygenation. These measurements can be performed over fields of view that range from millimeters to centimeters and probe up to the first few millimeters of rodent brain tissue. We discuss the principles and applications of three widefield optical imaging approaches that can measure cerebral hemodynamics: (1) optical intrinsic signal imaging, (2) laser speckle imaging, and (3) spatial frequency domain imaging. Future work in advancing widefield optical imaging approaches and employing multimodal instrumentation can enrich hemodynamic information content and help elucidate cerebrovascular mechanisms that lead to the development of therapeutic agents for AD and neurological injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.