Evidence map›Paper›PMID 37143860›Full record

ArticleBrain communications2023

Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer's disease.

Alexander K Song, Kilian Hett, Jarrod J Eisma, Colin D McKnight, Jason Elenberger, Adam J Stark, Hakmook Kang, Yan Yan, Ciaran M Considine, Manus J Donahue and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Arterial Spin Labeling MRI in Alzheimer's Disease: A Systematic Review of Cerebral Perfusion Biomarkers.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Neurofluid circulation changes during a focused attention style of mindfulness meditation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. The parasagittal dural space of the human brain.Brain : a journal of neurology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alexander K SongDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID https://orcid.org/0000-0003-1590-4144
Kilian HettDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jarrod J EismaDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Colin D McKnightDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jason ElenbergerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Adam J StarkDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Hakmook KangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 32732, USA.
Yan YanDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 32732, USA.
Ciaran M ConsidineDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Manus J DonahueDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Daniel O ClaassenDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Quantitative Imaging of Brain Glymphatic Function in HumansR01AG062574 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER, DONAHUE, MANUS J · 2020 to 2024
$3.0M
Quantitation of Glymphatic Functioning in Sleep and Meditative StatesR01AT011456 · NCCIH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER, DONAHUE, MANUS J · 2021 to 2023
$1.1M
NCCIH NIH HHS R01 AT011456NIA NIH HHS R01 AG062574NICHD NIH HHS P50 HD103537
6 · The paper itself

Abstract

One of the pathological hallmarks of Alzheimer's and related diseases is the increased accumulation of protein amyloid-β in the brain parenchyma. As such, recent studies have focused on characterizing protein and related clearance pathways involving perivascular flow of neurofluids, but human studies of these pathways are limited owing to limited methods for evaluating neurofluid circulation non-invasively

Indexed as

amyloid-βcerebrospinal fluidchoroid plexusglymphaticsparasagittal dural space

Identifiers

PMID37143860
PMCPMC10152899
OpenAlexW4366282150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.