ReviewFrontiers in endocrinology2023
Role of sex hormones in diabetic nephropathy.
Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathway.Renal failure · 2026Article
- Observational
- Temporal trends in mortality involving chronic lower respiratory disease and chronic kidney disease: evidence from CDC WONDER, 1999-2023.BMC nephrology · 2026Article
- Mesangial Cells (MES-SV40) Cultured in High Glucose Produce IL-36α, Which Is Associated with Type 2 Diabetes Mellitus.International journal of molecular sciences · 2026Article
- The double-edged sword effect of estrogen in kidney disease and its precision modulation.Frontiers in endocrinology · 2026Review
- Sex differences in retinal neurovascular changes in type 1 diabetes without retinopathy.International journal of ophthalmology · 2026Article
- Bioengineered exosome-mRNA hybrids: a breakthrough in targeted miRNA delivery for diabetic kidney fibrosis therapy.Frontiers in bioengineering and biotechnology · 2026Article
- Role of Sex Hormones in Mediating Adiposity Changes From Weight Loss in People With Type 2 Diabetes: Look AHEAD Sex Hormone Study.The Journal of clinical endocrinology and metabolism · 2025Article
- The association of plasma testosterone level and progression of diabetic nephropathy in male.BMC endocrine disorders · 2025Article
- The relationship between serum lipid levels and diabetic nephropathy in patients with primary diabetes.BMC nephrology · 2025Article
- Prevalence and risk factors of diabetic kidney disease in Malagasy patients with diabetes mellitus: a cross-sectional study at a University Hospital Center in Antananarivo, Madagascar.BMC nephrology · 2025Article
- Revealing the regulatory role of lncRNAs SNHG1 and CRNDE on Th17/Treg imbalance in diabetic kidney disease.Clinical and experimental medicine · 2025Article
- Epidemiological trends in diabetic renal complications in United States adults: A center for disease control and prevention wide-ranging online data for epidemiologic research analysis (1999-2020).World journal of nephrology · 2025Article
- Urinary Fetuin-A with Specific Post-Translational Modification in Type 1 Diabetes Patients with Normoalbuminuria and Preserved Kidney Function.Diagnostics (Basel, Switzerland) · 2025Article
- Association of Geriatric Nutritional Risk Index With Cardiovascular and All-Cause Mortality Among US Elderly Adults With Diabetic Nephropathy.Journal of diabetes research · 2025Article
- Global burden and trends of chronic kidney disease due to type 2 diabetes mellitus caused by dietary risks: insights from the global burden of disease study 2021.Frontiers in endocrinology · 2025Article
- Causal Associations of Iron Status With the Renal Function and Diabetic Nephropathy in Patients With Diabetes Mellitus: A Two-Sample Mendelian Randomization Study.Journal of diabetes research · 2025Article
- Sexual Dimorphism in Impairment of Acetylcholine-Mediated Vasorelaxation in Zucker Diabetic Fatty (ZDF) Rat Aorta: A Monogenic Model of Obesity-Induced Type 2 Diabetes.International journal of molecular sciences · 2024Article
- Testosterone deficiency and chronic kidney disease.Journal of clinical & translational endocrinology · 2024Review
- The Role of Estrogen across Multiple Disease Mechanisms.Current issues in molecular biology · 2024Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic nephropathy (DN) is the most common microvascular complication in diabetes and one of the leading causes of end-stage renal disease. The standard treatments for patients with classic DN focus on blood glucose and blood pressure control, but these treatments can only slow the progression of DN instead of stopping or reversing the disease. In recent years, new drugs targeting the pathological mechanisms of DN (e.g., blocking oxidative stress or inflammation) have emerged, and new therapeutic strategies targeting pathological mechanisms are gaining increasing attention. A growing number of epidemiological and clinical studies suggest that sex hormones play an important role in the onset and progression of DN. Testosterone is the main sex hormone in males and is thought to accelerate the occurrence and progression of DN. Estrogen is the main sex hormone in females and is thought to have renoprotective effects. However, the underlying molecular mechanism by which sex hormones regulate DN has not been fully elucidated and summarized. This review aims to summarize the correlation between sex hormones and DN and evaluate the value of hormonotherapy in DN.
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