Evidence map›Paper›PMID 37143680›Full record

ArticleFrontiers in immunology2023

Alpha4 beta7 integrin controls Th17 cell trafficking in the spinal cord leptomeninges during experimental autoimmune encephalomyelitis.

Barbara Rossi, Silvia Dusi, Gabriele Angelini, Alessandro Bani, Nicola Lopez, Vittorina Della Bianca, Enrica Caterina Pietronigro, Elena Zenaro, Carlotta Zocco, Gabriela Constantin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Life history of a brain autoreactive T cell: From thymus through intestine to blood-brain barrier and brain lesion.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Barbara RossiDepartment of Medicine, University of Verona, Verona, Italy.
Silvia DusiDepartment of Medicine, University of Verona, Verona, Italy.
Gabriele AngeliniDepartment of Medicine, University of Verona, Verona, Italy.
Alessandro BaniDepartment of Medicine, University of Verona, Verona, Italy.
Nicola LopezDepartment of Medicine, University of Verona, Verona, Italy.
Vittorina Della BiancaDepartment of Medicine, University of Verona, Verona, Italy.
Enrica Caterina PietronigroDepartment of Medicine, University of Verona, Verona, Italy.
Elena ZenaroDepartment of Medicine, University of Verona, Verona, Italy.
Carlotta ZoccoDepartment of Medicine, University of Verona, Verona, Italy.
Gabriela ConstantinDepartment of Medicine, University of Verona, Verona, Italy.
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Th1 and Th17 cell migration into the central nervous system (CNS) is a fundamental process in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). Particularly, leptomeningeal vessels of the subarachnoid space (SAS) constitute a central route for T cell entry into the CNS during EAE. Once migrated into the SAS, T cells show an active motility behavior, which is a prerequisite for cell-cell communication,

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalAnimalsIntegrin alpha4Integrin beta ChainsIntegrinsMiceNeuroinflammatory DiseasesSpinal CordTh17 CellsIntegrin alpha4integrin beta7Integrin beta ChainsIntegrinsalpha4 beta7 integrinexperimental autoimmune encephalomyelitisintravital microscopyleptomeningesTh17 cellsTh1 cells

Identifiers

PMID37143680
PMCPMC10151683
OpenAlexW4366292579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.