ArticleCerebral cortex (New York, N.Y. : 1991)2023
The role of the dorsolateral prefrontal cortex in control of skin sympathetic nerve activity in humans.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Penile sympathetic skin response in patients with non-organic erectile dysfunction: a Cross-Sectional Study.International journal of impotence research · 2026Article
- Cortical excitation does not drive changes in skin sympathetic nerve activity during single-pulse transcranial magnetic stimulation in humans.Experimental brain research · 2026Article
- Autonomic Imbalance in Cardiomyopathy and Heart Failure: From Neurobiology to Precision Neuromodulation.Current cardiology reports · 2025Review
- Sympathetic hyperactivity in situational delayed ejaculation (intravaginal anejaculation phenotype): a neurophysiological case-control study.Translational andrology and urology · 2025Article
- The Dorsolateral Prefrontal Cortex: A High-level Hub for Allostatic Cardiovascular Control.Current neuropharmacology · 2025Review
- Single-pulse transcranial magnetic stimulation of the dorsolateral prefrontal cortex does not directly affect muscle sympathetic nerve activity in humans.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Article
- Non-additive effects of electrical stimulation of the dorsolateral prefrontal cortex and the vestibular system on muscle sympathetic nerve activity in humans.Experimental brain research · 2024Article
- Neuroimaging-based evidence for sympathetic correlation between brain activity and peripheral vasomotion during pain anticipation.Scientific reports · 2024Article
- Differential control of sympathetic outflow to muscle and skin during physical and cognitive stressors.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Effect of transcutaneous neuromodulation on normalization of dermal body temperature and pain in a tender scar in the presence of low back pain: An update and case report.SAGE open medical case reports · 2024Article
- Top-down control of vestibular inputs by the dorsolateral prefrontal cortex.Experimental brain research · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorsolateral prefrontal cortex (dlPFC) is primarily involved in higher order executive functions, with there being evidence of lateralization. Brain imaging studies have revealed its link to the generation of skin sympathetic nerve activity (SSNA), which is elevated in states of emotional arousal or anxiety. However, no studies have directly explored dlPFC influences on SSNA. Transcranial alternating current stimulation (-2 to 2 mA, 0.08 Hz, 100 cycles) was applied between the left or right dlPFC and nasion via surface electrodes. Spontaneous bursts of SSNA were recorded from the common peroneal nerve via a tungsten microelectrode in 21 healthy participants. The modulation index was calculated for each stimulation paradigm by constructing cross-correlation histograms between SSNA and the sinusoidal stimulus. Stimulation of the dlPFC caused significant modulation of SSNA, but there was no significant difference in the median modulation index across sides. Stimulation also caused cyclic modulation of skin blood flow and sweat release. We have shown for the first time that stimulation of the dlPFC causes modulation of SSNA, also reflected in the effector-organ responses. This supports a role for the dlPFC in the control of SSNA, which likely contributes to the ability of emotions to bring about cutaneous vasoconstriction and sweat release.
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