Evidence map›Paper›PMID 37143038›Full record

ArticleBMC biology2023

Insights into the formation and diversification of a novel chiropteran wing membrane from embryonic development.

Neal Anthwal, Daniel J Urban, Alexa Sadier, Risa Takenaka, Simon Spiro, Nancy Simmons, Richard R Behringer, Chris J Cretekos, John J Rasweiler, Karen E Sears

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Neal Anthwal *Department of Ecology and Evolutionary Biology, University of California, Los Angeles, USA.
Daniel J Urban *Department of Ecology and Evolutionary Biology, University of California, Los Angeles, USA.
Alexa SadierDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, USA.
Risa TakenakaDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, USA.
Simon SpiroZoological Society of London, London, UK.
Nancy SimmonsDepartment of Mammalogy, Division of Vertebrate Biology, American Museum of Natural History, New York, USA.
Richard R BehringerDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, USA.
Chris J CretekosDepartment of Biology, Idaho State University, Pocatello, USA.
John J RasweilerDepartment of Obstetrics and Gynecology, State University of New York Downstate Medical Center, New York, USA.
Karen E SearsDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, USA. ksears@ucla.edu.ORCID 0000-0001-9744-9602
University of California, Los Angeles · USAmerican Museum of Natural History · USIdaho State University · USState University of New York · USThe University of Texas MD Anderson Cancer Center · USZoological Society of London · GB

Funding

Exploring the cellular mechanisms of enhanced lifespan in batsR21AG078784 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LYNCH, VINCENT J., SEARS, KAREN E · 2022 to 2023
$447k
NIA NIH HHS R21 AG078784
6 · The paper itself

Abstract

backgroundThrough the evolution of novel wing structures, bats (Order Chiroptera) became the only mammalian group to achieve powered flight. This achievement preceded the massive adaptive radiation of bats into diverse ecological niches. We investigate some of the developmental processes that underlie the origin and subsequent diversification of one of the novel membranes of the bat wing: the plagiopatagium, which connects the fore- and hind limb in all bat species.

resultsOur results suggest that the plagiopatagium initially arises through novel outgrowths from the body flank that subsequently merge with the limbs to generate the wing airfoil. Our findings further suggest that this merging process, which is highly conserved across bats, occurs through modulation of the programs controlling the development of the periderm of the epidermal epithelium. Finally, our results suggest that the shape of the plagiopatagium begins to diversify in bats only after this merging has occurred.

conclusionsThis study demonstrates how focusing on the evolution of cellular processes can inform an understanding of the developmental factors shaping the evolution of novel, highly adaptive structures.

Indexed as

ChiropteraAnimalsEmbryonic DevelopmentFlight, AnimalMammalsWings, AnimalBatsEvolutionary developmental biologyPeridermPlagiopatagiumWing membranes

Identifiers

PMID37143038
PMCPMC10161559
OpenAlexW4368617597

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.