Evidence map›Paper›PMID 37142904›Full record

ArticleJournal of autism and developmental disorders2024

Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy.

Michela Tinelli M, Aine Roddy, Martin Knapp, Celso Arango, Maria Andreina Mendez, James Cusack, Declan Murphy, Roberto Canitano, Bethany Oakley, Vinciane Quoidbach

Open access · hybridAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Michela Tinelli MCare Policy and Evaluation Centre, London School of Economics and Political Science, London, UK. m.tinelli@lse.ac.uk.ORCID http://orcid.org/0000-0002-8816-4389
Aine RoddyCare Policy and Evaluation Centre, London School of Economics and Political Science, London, UK.
Martin KnappCare Policy and Evaluation Centre, London School of Economics and Political Science, London, UK.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, School of Medicine, Hospital General Universitario Gregorio Marañón, Universidad Complutense, CIBERSAM, IiSGM, Madrid, Spain.
Maria Andreina MendezDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, School of Medicine, Hospital General Universitario Gregorio Marañón, Universidad Complutense, CIBERSAM, IiSGM, Madrid, Spain.
James CusackAutistica, London, UK.
Declan MurphyKings College London, London, UK.
Roberto Canitanoazienda - Azienda ospedaliero-universitaria Senese, Siena, Italy.
Bethany OakleyKings College London, London, UK.
Vinciane QuoidbachEuropean Brain Council, Bruxelles, Belgium.
Hospital General Universitario Gregorio Marañón · ESKing's College London · GBLondon School of Economics and Political Science · GBAtlantic Technological UniversityAutistica · GBAzienda Ospedaliera Universitaria Senese · IT

Funding

Commission européenne Office Européen de Lutte Antifraude n/a
6 · The paper itself

Abstract

We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children's families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure.

Indexed as

AnticonvulsantsAutistic DisorderCost-Benefit AnalysisEpilepsyAminesCarbamazepineChildEnglandFemaleGabapentingamma-Aminobutyric AcidHumansIrelandItalyMaleOxcarbazepineAminesAnticonvulsantsCarbamazepineGabapentingamma-Aminobutyric AcidOxcarbazepineAutismChildrenCost-effectivenessEpilepsyFamily impactsHealthcare expenditure

Identifiers

PMID37142904
PMCPMC11286621
OpenAlexW4368362410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.