Evidence map›Paper›PMID 37142773›Full record

ArticleNature microbiology2023

Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus.

Satoshi Ikegame, Jillian C Carmichael, Heather Wells, Robert L Furler O'Brien, Joshua A Acklin, Hsin-Ping Chiu, Kasopefoluwa Y Oguntuyo, Robert M Cox, Aum R Patel, Shreyas Kowdle and 14 more

Open access · bronzeAbstract read
In one paragraph

Article in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 3 countries.

Satoshi Ikegame *Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jillian C Carmichael *Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-5270-5916
Heather WellsDepartment of Ecology, Evolution and Environmental Biology, Columbia University, New York, NY, USA.ORCID 0000-0002-1724-5843
Robert L Furler O'BrienDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-5706-4871
Joshua A AcklinDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hsin-Ping ChiuDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kasopefoluwa Y OguntuyoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert M CoxInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0003-0620-1674
Aum R PatelDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7247-0349
Shreyas KowdleDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7786-3547
Christian S StevensDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Miles EckleyCenter for Vector-borne Infectious Diseases Department of Microbiology, Immunology and Pathology College of Veterinary Medicine Colorado State University, Fort Collins, CO, USA.
Shijun ZhanCenter for Vector-borne Infectious Diseases Department of Microbiology, Immunology and Pathology College of Veterinary Medicine Colorado State University, Fort Collins, CO, USA.
Jean K LimDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ethan C VeitDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3956-5928
Matthew J EvansDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Takao HashiguchiLaboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.ORCID 0000-0001-7578-7571
Edison DurigonDepartamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Tony SchountzCenter for Vector-borne Infectious Diseases Department of Microbiology, Immunology and Pathology College of Veterinary Medicine Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-1292-7650
Jonathan H EpsteinEcoHealth Alliance, New York, NY, USA.ORCID 0000-0002-1373-9301
Richard K PlemperInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0003-2034-2107
Peter DaszakEcoHealth Alliance, New York, NY, USA.ORCID 0000-0002-2046-5695
Simon J AnthonyDepartment of Pathology, Microbiology, and Immunology, UC Davis School of Veterinary Medicine, Davis, CA, USA.
Benhur LeeDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. benhur.lee@mssm.edu.ORCID 0000-0003-0760-1709
Icahn School of Medicine at Mount Sinai · USColorado State University · USEcoHealth Alliance · USGeorgia State University · USColumbia University · USCornell University · USKyoto University · JPUniversidade de São Paulo · BRUniversity of California, Davis · US

Funding

Project 6 - Development of Antivirals against AlphavirusesU19AI171403 · NIAID · EMORY UNIVERSITY · PI George Robert Painter, Richard K. Plemper · 2022 to 2026
$59.7M
TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5M
Identification and Pre-Clinical Evaluation of Measles Virus InhibitorsR01AI071002 · NIAID · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2006 to 2022
$6.6M
MERS coronavirus: antagonism of double-stranded RNA induced host response by accessory proteinsR01AI140442 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Susan R Weiss · 2018 to 2026
$5.1M
Polymerase Inhibitors of Respiratory Syncytial VirusR01AI153400 · NIAID · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2020 to 2024
$3.7M
Tropism, pathogenicity, and potential for zoonotic spillover of emergent henipa- and henipa-like virusesR01AI123449 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, BENHUR · 2016 to 2020
$2.7M
Biology and infection of bats with novel bat influenza virusesR01AI134768 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI MA, WENJUN · 2018 to 2022
$2.1M
Human Parainfluenza Virus 3 Infection in a Novel Human Lung Tissue ModelR21AI149033 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, BENHUR, LIM, JEAN KYOU · 2020 to 2021
$463k
Elucidating the molecular determinants of Henipavirus envelope-antibody and envelope-receptor interactions on viral entryF31AI154739 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OGUNTUYO, KASOPEFOLUWA Y. · 2020 to 2022
$135k
Elucidating Virus:Host Interactions of Human Parainfluenza Virus 3 in a Novel Human Lung Tissue Explant ModelF31HL149295 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ACKLIN, JOSHUA · 2020 to 2022
$109k
Determining Human Cytomegalovirus viral tropism and latency factors using Sendai virus-delivered CRISPR/Cas9F32HL158173 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARMICHAEL, JILLIAN · 2021 to 2021
$69k
NHLBI NIH HHS F31 HL149295NHLBI NIH HHS F32 HL158173NIAID NIH HHS F31 AI154739NIAID NIH HHS R01 AI071002NIAID NIH HHS R01 AI123449NIAID NIH HHS R01 AI134768NIAID NIH HHS R01 AI140442NIAID NIH HHS R01 AI153400NIAID NIH HHS R21 AI149033NIAID NIH HHS T32 AI007647NIAID NIH HHS U19 AI171403
6 · The paper itself

Abstract

Morbilliviruses are among the most contagious viral pathogens of mammals. Although previous metagenomic surveys have identified morbillivirus sequences in bats, full-length morbilliviruses from bats are limited. Here we characterize the myotis bat morbillivirus (MBaMV) from a bat surveillance programme in Brazil, whose full genome was recently published. We demonstrate that the fusion and receptor binding protein of MBaMV utilize bat CD150 and not human CD150, as an entry receptor in a mammalian cell line. Using reverse genetics, we produced a clone of MBaMV that infected Vero cells expressing bat CD150. Electron microscopy of MBaMV-infected cells revealed budding of pleomorphic virions, a characteristic morbillivirus feature. MBaMV replication reached 10

Indexed as

ChiropteraMorbillivirusAnimalsCell LineChlorocebus aethiopsHumansVero CellsZoonoses

Identifiers

PMID37142773
PMCPMC11089651
OpenAlexW4368373848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.