ArticleTranslational psychiatry2023
Depression and 24 gastrointestinal diseases: a Mendelian randomization study.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.Translational psychiatry · 2025Pooled it
- Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical evidence.Frontiers in pharmacology · 2025Pooled it
- Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways.BMC gastroenterology · 2024Pooled it
- Fecal microbiota from chronically stressed donors transfers behavioral and prefrontal cortex gene expression alterations to healthy recipient mice.Neurobiology of stress · 2026Article
- Association between antidepressant use and the risk of type 2 diabetes: a multi-stage Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between gastrointestinal diseases and depression severity among middle-aged and older Chinese women: the mediating effect of sleep duration.BMC psychiatry · 2026Observational
- Association between total body water and the risk of gastrointestinal symptoms: evidence from NHANES and Mendelian randomization analyses.BMC gastroenterology · 2026Article
- Integrative omics identify NID2 as a therapeutic target linking depression and colorectal cancer in humans.iScience · 2026Article
- A machine-learning-derived online screening tool for depressive symptoms in chronic digestive system diseases patients: a cross-sectional study with temporal validation from CHARLS.Scientific reports · 2026Article
- Joint associations of sleep quality and depressive symptoms with incident digestive disease in a nationally representative Chinese cohort.Scientific reports · 2026Article
- Bidirectional association between immune-mediated diseases and major depressive disorder: evidence from cohort, genome-wide pleiotropic, and experimental studies.Molecular psychiatry · 2026Article
- Impact of different stress paradigms on irritable bowel syndrome: Evidence from clinical and animal studies.The Journal of international medical research · 2026Review
- Observational
- Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study.Npj mental health research · 2026Article
- Association of depression and gastrointestinal diseases: a three-stage study.Psychological medicine · 2026Article
- Risk of Depression Related to Use of Proton Pump Inhibitors and Tegoprazan: A Nationwide Cohort Study.Journal of Korean medical science · 2026Article
- Depression and risk of gastro-oesophageal reflux disease (GERD): results from the UK Biobank study.BMC gastroenterology · 2026Article
- Associations of depression with incident liver and spleen diseases: a retrospective cohort study.BMC public health · 2026Article
- Vascular and autonomic correlates of screening-positive depressive symptom burden in chronic atrophic gastritis: a multicenter observational study protocol.Frontiers in medicine · 2026Article
- Chronic Stress Induces Hepatic Steatosis via Brain-Hepatic Sympathetic Axis Mediated Catecholamine Resistance.International journal of biological sciences · 2026Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The causality of the association between depression and gastrointestinal diseases is undetermined. We conducted Mendelian randomization (MR) analyses to systematically explore the associations of depression with 24 gastrointestinal diseases. Independent genetic variants associated with depression at the genome-wide significance level were selected as instrumental variables. Genetic associations with 24 gastrointestinal diseases were obtained from the UK Biobank study, the FinnGen study, and large consortia. Multivariable MR analysis was conducted to explore the mediation effects of body mass index, cigarette smoking, and type 2 diabetes. After multiple-testing corrections, genetic liability to depression was associated with an increased risk of irritable bowel syndrome, non-alcohol fatty liver disease, alcoholic liver disease, gastroesophageal reflux, chronic pancreatitis, duodenal ulcer, chronic gastritis, gastric ulcer, diverticular disease, cholelithiasis, acute pancreatitis, and ulcerative colitis. For the causal effect of genetic liability to depression on non-alcoholic fatty liver disease, a substantial proportion was mediated by body mass index. Genetic predisposition to smoking initiation mediated half of effect of depression on acute pancreatitis. This MR study suggests that depression may play a causal role in many gastrointestinal diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.